A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A

The progression of fibrosis in chronic liver disease is dependent upon hepatic stellate cells (HSCs) transdifferentiating to a myofibroblast-like phenotype. This pivotal process is controlled by enzymes that regulate histone methylation and chromatin structure, which may be targets for developing an...

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Detalles Bibliográficos
Autores principales: Zeybel, Müjdat, Luli, Saimir, Sabater, Laura, Hardy, Timothy, Oakley, Fiona, Leslie, Jack, Page, Agata, Moran Salvador, Eva, Sharkey, Victoria, Tsukamoto, Hidekazu, Chu, David C.K., Singh, Uma Sharan, Ponzoni, Mirco, Perri, Patrizia, Di Paolo, Daniela, Mendivil, Edgar J., Mann, Jelena, Mann, Derek A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363305/
https://www.ncbi.nlm.nih.gov/pubmed/28129116
http://dx.doi.org/10.1016/j.ymthe.2016.10.004

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