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Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting
Pre-existing antibodies (Abs) to AAV pose a critical challenge for the translation of gene therapies. No effective approach is available to overcome pre-existing Abs. Given the complexity of Ab production, overcoming pre-existing Abs will require broad immune targeting. We generated a mouse model of...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363314/ https://www.ncbi.nlm.nih.gov/pubmed/28345001 http://dx.doi.org/10.1016/j.omtm.2017.01.003 |