Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro

Tumor cells express a number of immunosuppressive molecules that can suppress anti-tumor immune responses. Efficient delivery of small interfering RNAs to treat a wide range of diseases including cancers remains a challenge. Retroviral replicating vectors (RRV) can be used to stably and selectively...

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Detalles Bibliográficos
Autores principales: Lin, Amy H., Twitty, Christopher G., Burnett, Ryan, Hofacre, Andrew, Mitchell, Leah A., Espinoza, Fernando Lopez, Gruber, Harry E., Jolly, Douglas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363416/
https://www.ncbi.nlm.nih.gov/pubmed/28325288
http://dx.doi.org/10.1016/j.omtn.2016.11.007

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