Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

In early gene therapy trials for SCID-X1, using γ-retroviral vectors, T cell leukemias developed in a subset of patients secondary to insertional proto-oncogene activation. In contrast, we have reported development of T cell leukemias in SCID-X1 mice following lentivirus-mediated gene therapy indepe...

Descripción completa

Detalles Bibliográficos
Autores principales: Ginn, Samantha L., Hallwirth, Claus V., Liao, Sophia H.Y., Teber, Erdahl T., Arthur, Jonathan W., Wu, Jianmin, Lee, Hong Ching, Tay, Szun S., Hu, Min, Reddel, Roger R., McCormack, Matthew P., Thrasher, Adrian J., Cavazzana, Marina, Alexander, Stephen I., Alexander, Ian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363493/
https://www.ncbi.nlm.nih.gov/pubmed/28325276
http://dx.doi.org/10.1016/j.omtn.2016.11.011

Ejemplares similares

Ejemplares similares