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Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA
RNAi by short hairpin RNA (shRNA) is a powerful tool not only for studying gene functions in various organisms, including mammals, but also for the treatment of severe disorders. However, shRNA-expressing vectors can induce type I interferon (IFN) expression by activation of innate immune responses,...
Autores principales: | Machitani, Mitsuhiro, Sakurai, Fuminori, Wakabayashi, Keisaku, Takayama, Kosuke, Tachibana, Masashi, Mizuguchi, Hiroyuki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363498/ https://www.ncbi.nlm.nih.gov/pubmed/28325284 http://dx.doi.org/10.1016/j.omtn.2016.12.007 |
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