siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K-ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer

There is an unmet need in the development of an effective therapy for mutant K-ras-expressing non-small-cell lung cancer (NSCLC). Although various small molecules have been evaluated, an effective therapy remains a dream. siRNAs have the potential to downregulate mutant K-ras both at the protein and...

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Detalles Bibliográficos
Autores principales: Perepelyuk, Maryna, Shoyele, Olubunmi, Birbe, Ruth, Thangavel, Chellappagounder, Liu, Yi, Den, Robert B., Snook, Adam E., Lu, Bo, Shoyele, Sunday A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363504/
https://www.ncbi.nlm.nih.gov/pubmed/28325292
http://dx.doi.org/10.1016/j.omtn.2016.12.009

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