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Abnormal amphiregulin expression correlates with gastric cancer prognosis
Gastric cancer (GC) is a global health issue with a high mortality rate. Early diagnosis and tracking of GC is a challenge due to a lack of reliable tools. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family that activates growth signaling upon binding of EGF receptors. Eleva...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363540/ https://www.ncbi.nlm.nih.gov/pubmed/27713123 http://dx.doi.org/10.18632/oncotarget.12436 |
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author | Wang, Bing Yong, Hongmei Zhu, Huijun Ni, Daguang Tang, Sijie Zhang, Shu Wang, Wei Zhou, Yan Zhao, Wei Ding, Guipeng Zhu, Jin Li, Xiaohua Feng, Zhenqing |
author_facet | Wang, Bing Yong, Hongmei Zhu, Huijun Ni, Daguang Tang, Sijie Zhang, Shu Wang, Wei Zhou, Yan Zhao, Wei Ding, Guipeng Zhu, Jin Li, Xiaohua Feng, Zhenqing |
author_sort | Wang, Bing |
collection | PubMed |
description | Gastric cancer (GC) is a global health issue with a high mortality rate. Early diagnosis and tracking of GC is a challenge due to a lack of reliable tools. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family that activates growth signaling upon binding of EGF receptors. Elevated AREG expression is associated with various pathological conditions, including cancer. Here, we investigated whether increased AREG expression is a disease indicator and/or prognostic biomarker for GC. We used tissue microarray and quantitative real-time polymerase chain reaction to assess AREG expression in clinical tissue specimens at various stages of GC and a conducted bioinformatics analysis to evaluate the value of AREG over-expression as a GC biomarker. We found that both mRNA and protein expression of AREG were increased in the tissues of GC patients when compared to tissues from non-cancer patients or normal tissues. High expression of AREG was also associated with GC clinicopathological characteristics and poor survival. Thus, over-expression of AREG could serve as a novel GC biomarker, and active surveillance of its expression could be a novel approach to GC diagnosis and monitoring. |
format | Online Article Text |
id | pubmed-5363540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53635402017-03-29 Abnormal amphiregulin expression correlates with gastric cancer prognosis Wang, Bing Yong, Hongmei Zhu, Huijun Ni, Daguang Tang, Sijie Zhang, Shu Wang, Wei Zhou, Yan Zhao, Wei Ding, Guipeng Zhu, Jin Li, Xiaohua Feng, Zhenqing Oncotarget Research Paper Gastric cancer (GC) is a global health issue with a high mortality rate. Early diagnosis and tracking of GC is a challenge due to a lack of reliable tools. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family that activates growth signaling upon binding of EGF receptors. Elevated AREG expression is associated with various pathological conditions, including cancer. Here, we investigated whether increased AREG expression is a disease indicator and/or prognostic biomarker for GC. We used tissue microarray and quantitative real-time polymerase chain reaction to assess AREG expression in clinical tissue specimens at various stages of GC and a conducted bioinformatics analysis to evaluate the value of AREG over-expression as a GC biomarker. We found that both mRNA and protein expression of AREG were increased in the tissues of GC patients when compared to tissues from non-cancer patients or normal tissues. High expression of AREG was also associated with GC clinicopathological characteristics and poor survival. Thus, over-expression of AREG could serve as a novel GC biomarker, and active surveillance of its expression could be a novel approach to GC diagnosis and monitoring. Impact Journals LLC 2016-10-04 /pmc/articles/PMC5363540/ /pubmed/27713123 http://dx.doi.org/10.18632/oncotarget.12436 Text en Copyright: © 2016 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Wang, Bing Yong, Hongmei Zhu, Huijun Ni, Daguang Tang, Sijie Zhang, Shu Wang, Wei Zhou, Yan Zhao, Wei Ding, Guipeng Zhu, Jin Li, Xiaohua Feng, Zhenqing Abnormal amphiregulin expression correlates with gastric cancer prognosis |
title | Abnormal amphiregulin expression correlates with gastric cancer prognosis |
title_full | Abnormal amphiregulin expression correlates with gastric cancer prognosis |
title_fullStr | Abnormal amphiregulin expression correlates with gastric cancer prognosis |
title_full_unstemmed | Abnormal amphiregulin expression correlates with gastric cancer prognosis |
title_short | Abnormal amphiregulin expression correlates with gastric cancer prognosis |
title_sort | abnormal amphiregulin expression correlates with gastric cancer prognosis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363540/ https://www.ncbi.nlm.nih.gov/pubmed/27713123 http://dx.doi.org/10.18632/oncotarget.12436 |
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