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Abnormal amphiregulin expression correlates with gastric cancer prognosis

Gastric cancer (GC) is a global health issue with a high mortality rate. Early diagnosis and tracking of GC is a challenge due to a lack of reliable tools. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family that activates growth signaling upon binding of EGF receptors. Eleva...

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Autores principales: Wang, Bing, Yong, Hongmei, Zhu, Huijun, Ni, Daguang, Tang, Sijie, Zhang, Shu, Wang, Wei, Zhou, Yan, Zhao, Wei, Ding, Guipeng, Zhu, Jin, Li, Xiaohua, Feng, Zhenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363540/
https://www.ncbi.nlm.nih.gov/pubmed/27713123
http://dx.doi.org/10.18632/oncotarget.12436
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author Wang, Bing
Yong, Hongmei
Zhu, Huijun
Ni, Daguang
Tang, Sijie
Zhang, Shu
Wang, Wei
Zhou, Yan
Zhao, Wei
Ding, Guipeng
Zhu, Jin
Li, Xiaohua
Feng, Zhenqing
author_facet Wang, Bing
Yong, Hongmei
Zhu, Huijun
Ni, Daguang
Tang, Sijie
Zhang, Shu
Wang, Wei
Zhou, Yan
Zhao, Wei
Ding, Guipeng
Zhu, Jin
Li, Xiaohua
Feng, Zhenqing
author_sort Wang, Bing
collection PubMed
description Gastric cancer (GC) is a global health issue with a high mortality rate. Early diagnosis and tracking of GC is a challenge due to a lack of reliable tools. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family that activates growth signaling upon binding of EGF receptors. Elevated AREG expression is associated with various pathological conditions, including cancer. Here, we investigated whether increased AREG expression is a disease indicator and/or prognostic biomarker for GC. We used tissue microarray and quantitative real-time polymerase chain reaction to assess AREG expression in clinical tissue specimens at various stages of GC and a conducted bioinformatics analysis to evaluate the value of AREG over-expression as a GC biomarker. We found that both mRNA and protein expression of AREG were increased in the tissues of GC patients when compared to tissues from non-cancer patients or normal tissues. High expression of AREG was also associated with GC clinicopathological characteristics and poor survival. Thus, over-expression of AREG could serve as a novel GC biomarker, and active surveillance of its expression could be a novel approach to GC diagnosis and monitoring.
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spelling pubmed-53635402017-03-29 Abnormal amphiregulin expression correlates with gastric cancer prognosis Wang, Bing Yong, Hongmei Zhu, Huijun Ni, Daguang Tang, Sijie Zhang, Shu Wang, Wei Zhou, Yan Zhao, Wei Ding, Guipeng Zhu, Jin Li, Xiaohua Feng, Zhenqing Oncotarget Research Paper Gastric cancer (GC) is a global health issue with a high mortality rate. Early diagnosis and tracking of GC is a challenge due to a lack of reliable tools. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family that activates growth signaling upon binding of EGF receptors. Elevated AREG expression is associated with various pathological conditions, including cancer. Here, we investigated whether increased AREG expression is a disease indicator and/or prognostic biomarker for GC. We used tissue microarray and quantitative real-time polymerase chain reaction to assess AREG expression in clinical tissue specimens at various stages of GC and a conducted bioinformatics analysis to evaluate the value of AREG over-expression as a GC biomarker. We found that both mRNA and protein expression of AREG were increased in the tissues of GC patients when compared to tissues from non-cancer patients or normal tissues. High expression of AREG was also associated with GC clinicopathological characteristics and poor survival. Thus, over-expression of AREG could serve as a novel GC biomarker, and active surveillance of its expression could be a novel approach to GC diagnosis and monitoring. Impact Journals LLC 2016-10-04 /pmc/articles/PMC5363540/ /pubmed/27713123 http://dx.doi.org/10.18632/oncotarget.12436 Text en Copyright: © 2016 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Bing
Yong, Hongmei
Zhu, Huijun
Ni, Daguang
Tang, Sijie
Zhang, Shu
Wang, Wei
Zhou, Yan
Zhao, Wei
Ding, Guipeng
Zhu, Jin
Li, Xiaohua
Feng, Zhenqing
Abnormal amphiregulin expression correlates with gastric cancer prognosis
title Abnormal amphiregulin expression correlates with gastric cancer prognosis
title_full Abnormal amphiregulin expression correlates with gastric cancer prognosis
title_fullStr Abnormal amphiregulin expression correlates with gastric cancer prognosis
title_full_unstemmed Abnormal amphiregulin expression correlates with gastric cancer prognosis
title_short Abnormal amphiregulin expression correlates with gastric cancer prognosis
title_sort abnormal amphiregulin expression correlates with gastric cancer prognosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363540/
https://www.ncbi.nlm.nih.gov/pubmed/27713123
http://dx.doi.org/10.18632/oncotarget.12436
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