TGF-β signal rewiring sustains epithelial-mesenchymal transition of circulating tumor cells in prostate cancer xenograft hosts

Activation of TGF-β signaling is known to promote epithelial-mesenchymal transition (EMT) for the development of metastatic castration-resistant prostate cancer (mCRPC). To determine whether targeting TGF-β signaling alone is sufficient to mitigate mCRPC, we used the CRISPR/Cas9 genome-editing appro...

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Detalles Bibliográficos
Autores principales: Huang, Guangcun, Osmulski, Pawel A., Bouamar, Hakim, Mahalingam, Devalingam, Lin, Chun-Lin, Liss, Michael A., Kumar, Addanki Pratap, Chen, Chun-Liang, Thompson, Ian M., Sun, Lu-Zhe, Gaczynska, Maria E., Huang, Tim H.-M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363574/
https://www.ncbi.nlm.nih.gov/pubmed/27780930
http://dx.doi.org/10.18632/oncotarget.12808

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