Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer

Epidermal growth factor receptor (EGFR)-targeted tyrosine kinase inhibitors (TKIs) have emerged as first-line drugs for non-small cell lung cancers (NSCLCs). However, the resistance to TKIs represents the key limitation for their therapeutic efficacy. We found that the difference of OCT4 expression...

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Detalles Bibliográficos
Autores principales: Li, Bin, Yao, Zhouhong, Wan, Yunyan, Lin, Dianjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363589/
https://www.ncbi.nlm.nih.gov/pubmed/27816965
http://dx.doi.org/10.18632/oncotarget.12999
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author Li, Bin
Yao, Zhouhong
Wan, Yunyan
Lin, Dianjie
author_facet Li, Bin
Yao, Zhouhong
Wan, Yunyan
Lin, Dianjie
author_sort Li, Bin
collection PubMed
description Epidermal growth factor receptor (EGFR)-targeted tyrosine kinase inhibitors (TKIs) have emerged as first-line drugs for non-small cell lung cancers (NSCLCs). However, the resistance to TKIs represents the key limitation for their therapeutic efficacy. We found that the difference of OCT4 expression between NSCLC and the adjacent non-tumourous tissues was statistically significant. Knockdown of OCT4 in NSCLC cells could decrease cell proliferation, and potentiate apoptosis induced by gefitinib, suggesting OCT4 may contribute to gefitinib resistance in NSCLC.
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spelling pubmed-53635892017-03-29 Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer Li, Bin Yao, Zhouhong Wan, Yunyan Lin, Dianjie Oncotarget Research Paper Epidermal growth factor receptor (EGFR)-targeted tyrosine kinase inhibitors (TKIs) have emerged as first-line drugs for non-small cell lung cancers (NSCLCs). However, the resistance to TKIs represents the key limitation for their therapeutic efficacy. We found that the difference of OCT4 expression between NSCLC and the adjacent non-tumourous tissues was statistically significant. Knockdown of OCT4 in NSCLC cells could decrease cell proliferation, and potentiate apoptosis induced by gefitinib, suggesting OCT4 may contribute to gefitinib resistance in NSCLC. Impact Journals LLC 2016-10-31 /pmc/articles/PMC5363589/ /pubmed/27816965 http://dx.doi.org/10.18632/oncotarget.12999 Text en Copyright: © 2016 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Li, Bin
Yao, Zhouhong
Wan, Yunyan
Lin, Dianjie
Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer
title Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer
title_full Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer
title_fullStr Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer
title_full_unstemmed Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer
title_short Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer
title_sort overexpression of oct4 is associated with gefitinib resistance in non-small cell lung cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363589/
https://www.ncbi.nlm.nih.gov/pubmed/27816965
http://dx.doi.org/10.18632/oncotarget.12999
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AT lindianjie overexpressionofoct4isassociatedwithgefitinibresistanceinnonsmallcelllungcancer

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