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Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo
Mutation of p53 occasionally results in a gain of function, which promotes tumor growth. We asked whether destabilizing the gain-of-function protein would kill tumor cells. Downregulation of the gene reduced cell proliferation in p53-mutant cells, but not in p53-null cells, indicating that the forme...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363612/ https://www.ncbi.nlm.nih.gov/pubmed/27765910 http://dx.doi.org/10.18632/oncotarget.12758 |