Transposon-mediated generation of BCR-ABL1-expressing transgenic cell lines for unbiased sensitivity testing of tyrosine kinase inhibitors

Point mutations in the ABL1 kinase domain are an important mechanism of resistance to tyrosine kinase inhibitors (TKI) in BCR-ABL1-positive and, as recently shown, BCR-ABL1-like leukemias. The cell line Ba/F3 lentivirally transduced with mutant BCR-ABL1 constructs is widely used for in vitro sensiti...

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Detalles Bibliográficos
Autores principales: Byrgazov, Konstantin, Lucini, Chantal Blanche, Berkowitsch, Bettina, Koenig, Margit, Haas, Oskar A., Hoermann, Gregor, Valent, Peter, Lion, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363645/
https://www.ncbi.nlm.nih.gov/pubmed/27801667
http://dx.doi.org/10.18632/oncotarget.12943

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