Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators

Enadenotucirev (EnAd) is a chimeric group B adenovirus isolated by bioselection from a library of adenovirus serotypes. It replicates selectively in and kills a diverse range of carcinoma cells, shows effective anticancer activity in preclinical systems, and is currently undergoing phase I/II clinic...

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Detalles Bibliográficos
Autores principales: Dyer, Arthur, Di, Ying, Calderon, Hugo, Illingworth, Sam, Kueberuwa, Gray, Tedcastle, Alison, Jakeman, Phil, Chia, Suet Lin, Brown, Alice, Silva, Michael A., Barlow, David, Beadle, John, Hermiston, Terry, Ferguson, David J.P., Champion, Brian, Fisher, Kerry D., Seymour, Leonard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363721/
https://www.ncbi.nlm.nih.gov/pubmed/28345021
http://dx.doi.org/10.1016/j.omto.2016.11.003

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