Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma

Despite improved survival for children with newly diagnosed neuroblastoma (NB), recurrent disease is a significant problem, with treatment options limited by anti-tumor efficacy, patient drug tolerance, and cumulative toxicity. We previously demonstrated that neural stem cells (NSCs) expressing a mo...

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Detalles Bibliográficos
Autores principales: Gutova, Margarita, Goldstein, Leanne, Metz, Marianne, Hovsepyan, Anahit, Tsurkan, Lyudmila G., Tirughana, Revathiswari, Tsaturyan, Lusine, Annala, Alexander J., Synold, Timothy W., Wan, Zesheng, Seeger, Robert, Anderson, Clarke, Moats, Rex A., Potter, Philip M., Aboody, Karen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363723/
https://www.ncbi.nlm.nih.gov/pubmed/28345025
http://dx.doi.org/10.1016/j.omto.2016.11.004

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