Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks

Novel antimalarial therapies are urgently needed for the fight against drug-resistant parasites. The metabolism of malaria parasites in infected cells is an attractive source of drug targets but is rather complex. Computational methods can handle this complexity and allow integrative analyses of cel...

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Detalles Bibliográficos
Autores principales: Chiappino-Pepe, Anush, Tymoshenko, Stepan, Ataman, Meriç, Soldati-Favre, Dominique, Hatzimanikatis, Vassily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363809/
https://www.ncbi.nlm.nih.gov/pubmed/28333921
http://dx.doi.org/10.1371/journal.pcbi.1005397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363809/
https://www.ncbi.nlm.nih.gov/pubmed/28333921
http://dx.doi.org/10.1371/journal.pcbi.1005397

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