Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity

A series of N,4-diaryl-1,3-thiazole-2-amines containing three aromatic rings with an amino linker were designed and synthesized as tubulin inhibitors and evaluated for their antiproliferative activity in three human cancer cell lines. Most of the target compounds displayed moderate antiproliferative...

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Detalles Bibliográficos
Autores principales: Sun, Maolin, Xu, Qile, Xu, Jingwen, Wu, Yue, Wang, Yueting, Zuo, Daiying, Guan, Qi, Bao, Kai, Wang, Jian, Wu, Yingliang, Zhang, Weige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363846/
https://www.ncbi.nlm.nih.gov/pubmed/28333984
http://dx.doi.org/10.1371/journal.pone.0174006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363846/
https://www.ncbi.nlm.nih.gov/pubmed/28333984
http://dx.doi.org/10.1371/journal.pone.0174006

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