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The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt

The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated via Notch’s interaction with the canonical Wnt pathway. Here, we propose a new mathematical model of the Notch and Wnt p...

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Detalles Bibliográficos
Autores principales:	Kay, Sophie K., Harrington, Heather A., Shepherd, Sarah, Brennan, Keith, Dale, Trevor, Osborne, James M., Gavaghan, David J., Byrne, Helen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363986/ https://www.ncbi.nlm.nih.gov/pubmed/28245235 http://dx.doi.org/10.1371/journal.pcbi.1005400

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