Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate

This article describes apparatus to aid histological validation of magnetic resonance imaging studies of the human prostate. The apparatus includes a 3D-printed patient-specific mold that facilitates aligned in vivo and ex vivo imaging, in situ tissue fixation, and tissue sectioning with minimal org...

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Detalles Bibliográficos
Autores principales: Bourne, Roger M., Bailey, Colleen, Johnston, Edward William, Pye, Hayley, Heavey, Susan, Whitaker, Hayley, Siow, Bernard, Freeman, Alex, Shaw, Greg L., Sridhar, Ashwin, Mertzanidou, Thomy, Hawkes, David J., Alexander, Daniel C., Punwani, Shonit, Panagiotaki, Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364138/
https://www.ncbi.nlm.nih.gov/pubmed/28393049
http://dx.doi.org/10.3389/fonc.2017.00047
Descripción
Sumario:This article describes apparatus to aid histological validation of magnetic resonance imaging studies of the human prostate. The apparatus includes a 3D-printed patient-specific mold that facilitates aligned in vivo and ex vivo imaging, in situ tissue fixation, and tissue sectioning with minimal organ deformation. The mold and a dedicated container include MRI-visible landmarks to enable consistent tissue positioning and minimize image registration complexity. The inclusion of high spatial resolution ex vivo imaging aids in registration of in vivo MRI and histopathology data.

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