Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate

This article describes apparatus to aid histological validation of magnetic resonance imaging studies of the human prostate. The apparatus includes a 3D-printed patient-specific mold that facilitates aligned in vivo and ex vivo imaging, in situ tissue fixation, and tissue sectioning with minimal org...

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Autores principales: Bourne, Roger M., Bailey, Colleen, Johnston, Edward William, Pye, Hayley, Heavey, Susan, Whitaker, Hayley, Siow, Bernard, Freeman, Alex, Shaw, Greg L., Sridhar, Ashwin, Mertzanidou, Thomy, Hawkes, David J., Alexander, Daniel C., Punwani, Shonit, Panagiotaki, Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364138/
https://www.ncbi.nlm.nih.gov/pubmed/28393049
http://dx.doi.org/10.3389/fonc.2017.00047
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author Bourne, Roger M.
Bailey, Colleen
Johnston, Edward William
Pye, Hayley
Heavey, Susan
Whitaker, Hayley
Siow, Bernard
Freeman, Alex
Shaw, Greg L.
Sridhar, Ashwin
Mertzanidou, Thomy
Hawkes, David J.
Alexander, Daniel C.
Punwani, Shonit
Panagiotaki, Eleftheria
author_facet Bourne, Roger M.
Bailey, Colleen
Johnston, Edward William
Pye, Hayley
Heavey, Susan
Whitaker, Hayley
Siow, Bernard
Freeman, Alex
Shaw, Greg L.
Sridhar, Ashwin
Mertzanidou, Thomy
Hawkes, David J.
Alexander, Daniel C.
Punwani, Shonit
Panagiotaki, Eleftheria
author_sort Bourne, Roger M.
collection PubMed
description This article describes apparatus to aid histological validation of magnetic resonance imaging studies of the human prostate. The apparatus includes a 3D-printed patient-specific mold that facilitates aligned in vivo and ex vivo imaging, in situ tissue fixation, and tissue sectioning with minimal organ deformation. The mold and a dedicated container include MRI-visible landmarks to enable consistent tissue positioning and minimize image registration complexity. The inclusion of high spatial resolution ex vivo imaging aids in registration of in vivo MRI and histopathology data.
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spelling pubmed-53641382017-04-07 Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate Bourne, Roger M. Bailey, Colleen Johnston, Edward William Pye, Hayley Heavey, Susan Whitaker, Hayley Siow, Bernard Freeman, Alex Shaw, Greg L. Sridhar, Ashwin Mertzanidou, Thomy Hawkes, David J. Alexander, Daniel C. Punwani, Shonit Panagiotaki, Eleftheria Front Oncol Oncology This article describes apparatus to aid histological validation of magnetic resonance imaging studies of the human prostate. The apparatus includes a 3D-printed patient-specific mold that facilitates aligned in vivo and ex vivo imaging, in situ tissue fixation, and tissue sectioning with minimal organ deformation. The mold and a dedicated container include MRI-visible landmarks to enable consistent tissue positioning and minimize image registration complexity. The inclusion of high spatial resolution ex vivo imaging aids in registration of in vivo MRI and histopathology data. Frontiers Media S.A. 2017-03-24 /pmc/articles/PMC5364138/ /pubmed/28393049 http://dx.doi.org/10.3389/fonc.2017.00047 Text en Copyright © 2017 Bourne, Bailey, Johnston, Pye, Heavey, Whitaker, Siow, Freeman, Shaw, Sridhar, Mertzanidou, Hawkes, Alexander, Punwani and Panagiotaki. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bourne, Roger M.
Bailey, Colleen
Johnston, Edward William
Pye, Hayley
Heavey, Susan
Whitaker, Hayley
Siow, Bernard
Freeman, Alex
Shaw, Greg L.
Sridhar, Ashwin
Mertzanidou, Thomy
Hawkes, David J.
Alexander, Daniel C.
Punwani, Shonit
Panagiotaki, Eleftheria
Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate
title Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate
title_full Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate
title_fullStr Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate
title_full_unstemmed Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate
title_short Apparatus for Histological Validation of In Vivo and Ex Vivo Magnetic Resonance Imaging of the Human Prostate
title_sort apparatus for histological validation of in vivo and ex vivo magnetic resonance imaging of the human prostate
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364138/
https://www.ncbi.nlm.nih.gov/pubmed/28393049
http://dx.doi.org/10.3389/fonc.2017.00047
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