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Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase

Type II DNA-topoisomerases (topo II) play a crucial role in the maintenance of DNA topology. Previously, fungi of the Alternaria genus were found to produce mycotoxins that target human topo II. These results implied the question why a fungus should produce secondary metabolites that target a human...

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Detalles Bibliográficos
Autores principales:	Jarolim, Katharina, Del Favero, Giorgia, Ellmer, Doris, Stark, Timo D., Hofmann, Thomas, Sulyok, Michael, Humpf, Hans-Ulrich, Marko, Doris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Biologics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364253/ https://www.ncbi.nlm.nih.gov/pubmed/27682608 http://dx.doi.org/10.1007/s00204-016-1855-z

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