Cargando…

Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication

Acute organophosphorus (OP) intoxication is a worldwide clinical and public health problem. In addition to cholinergic crisis, neurodegeneration and brain damage are hallmarks of the severe form of this toxidrome. Recently, we generated a chemical model of severe acute OP intoxication in zebrafish t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Faria, Melissa, Prats, Eva, Padrós, Francesc, Soares, Amadeu M. V. M., Raldúa, Demetrio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Organ Toxicity and Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364264/ https://www.ncbi.nlm.nih.gov/pubmed/27655295 http://dx.doi.org/10.1007/s00204-016-1851-3

Ejemplares similares

Analysis of the neurotoxic effects of neuropathic organophosphorus compounds in adult zebrafish
por: Faria, Melissa, et al.
Publicado: (2018)

Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model
por: Hogberg, Helena T., et al.
Publicado: (2020)

Organophosphorus pesticides exhibit compound specific effects in rat precision-cut lung slices (PCLS): mechanisms involved in airway response, cytotoxicity, inflammatory activation and antioxidative defense
por: Tigges, Jonas, et al.
Publicado: (2021)

Zebrafish Models for Human Acute Organophosphorus Poisoning
por: Faria, Melissa, et al.
Publicado: (2015)

Corrigendum: Zebrafish Models for Human Acute Organophosphorus Poisoning
por: Faria, Melissa, et al.
Publicado: (2016)

GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes
por: Karhu, S. Tuuli, et al.
Publicado: (2020)

Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?
por: Brotzmann, Katharina, et al.
Publicado: (2020)

Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p′-DDT in U937 macrophages
por: Sciullo, Eric M., et al.
Publicado: (2010)

Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analogues
por: Brotzmann, Katharina, et al.
Publicado: (2022)

Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
por: Xiong, Rui, et al.
Publicado: (2021)

Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer
por: Kyriakides, Michael, et al.
Publicado: (2016)

New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis
por: Souza, Terezinha, et al.
Publicado: (2015)

Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells
por: Ramirez, Tzutzuy, et al.
Publicado: (2017)

Intermittent convection-enhanced delivery of GDNF into rhesus monkey putamen: absence of local or cerebellar toxicity
por: Luz, Matthias, et al.
Publicado: (2018)

MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2016)

Inhibition of neurite outgrowth and enhanced effects compared to baseline toxicity in SH-SY5Y cells
por: Lee, Jungeun, et al.
Publicado: (2022)

Prediction of the dose range for adverse neurological effects of amiodarone in patients from an in vitro toxicity test by in vitro–in vivo extrapolation
por: Algharably, Engi Abd el-Hady, et al.
Publicado: (2021)

Assessment of cochlear toxicity in response to chronic 3,3′-iminodipropionitrile in mice reveals early and reversible functional loss that precedes overt histopathology
por: Greguske, Erin A., et al.
Publicado: (2021)

An ex vivo perfused ventilated murine lung model suggests lack of acute pulmonary toxicity of the potential novel anticancer agent (−)-englerin A
por: Schremmer, Christian, et al.
Publicado: (2022)

Evaluation of toxicity of aerosols from flavored e-liquids in Sprague–Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis
por: Ho, Jenny, et al.
Publicado: (2020)

Combined biological effects and lung proteomics analysis in mice reveal different toxic impacts of electronic cigarette aerosol and combustible cigarette smoke on the respiratory system
por: Yang, Wanchun, et al.
Publicado: (2022)

The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans
por: Maroto, Alberto F., et al.
Publicado: (2023)

Unraveling the mechanisms underlying drug-induced cholestatic liver injury: identifying key genes using machine learning techniques on human in vitro data sets
por: Jiang, Jian, et al.
Publicado: (2023)

Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells
por: Hoogstraten, Charlotte A., et al.
Publicado: (2023)

The cyanobacterial neurotoxin β-N-methylamino-l-alanine (BMAA) targets the olfactory bulb region
por: Pierozan, Paula, et al.
Publicado: (2020)

Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA
por: Karlsson, Oskar, et al.
Publicado: (2014)

Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes
por: Garcia-Reyero, Natàlia, et al.
Publicado: (2016)

Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone
por: Shi, Miaoying, et al.
Publicado: (2020)

Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach
por: Vatakuti, Suresh, et al.
Publicado: (2016)

In vitro–in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans
por: Shi, Miaoying, et al.
Publicado: (2022)

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
por: Tolosa, Laia, et al.
Publicado: (2017)

GABA(A) receptor subtype selectivity of the proconvulsant rodenticide TETS
por: Pressly, Brandon, et al.
Publicado: (2017)

Serotonin involvement in okadaic acid-induced diarrhoea in vivo
por: Louzao, M. Carmen, et al.
Publicado: (2021)

Discovery of treatment for nerve agents targeting a new metabolic pathway
por: Glaros, Trevor, et al.
Publicado: (2020)

Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validation
por: Kadioglu, Onat, et al.
Publicado: (2021)

Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?
por: Joosen, Marloes J. A., et al.
Publicado: (2010)

Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis
por: Andronis, Christos, et al.
Publicado: (2020)

Nitrofurantoin-induced liver injury: long-term follow-up in two prospective DILI registries
por: Bessone, Fernando, et al.
Publicado: (2022)

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
por: Sison-Young, Rowena L., et al.
Publicado: (2016)

Acute airway irritation of methyl formate in mice
por: Larsen, Søren T., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_edf4vttpmas2lp44i2kesrj15e