Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone

Exposure to aristolochic acid (AA) causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN). Conflicting results have been found for the role of human sulfotransferase 1A1 (SULT1A1) contributing to the metabolic activation of aristolochic acid I (AAI) in vitro. We evaluated th...

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Detalles Bibliográficos
Autores principales: Arlt, Volker M., Meinl, Walter, Florian, Simone, Nagy, Eszter, Barta, Frantisek, Thomann, Marlies, Mrizova, Iveta, Krais, Annette M., Liu, Maggie, Richards, Meirion, Mirza, Amin, Kopka, Klaus, Phillips, David H., Glatt, Hansruedi, Stiborova, Marie, Schmeiser, Heinz H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364269/
https://www.ncbi.nlm.nih.gov/pubmed/27557898
http://dx.doi.org/10.1007/s00204-016-1808-6

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