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Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory
Recognition memory enables us to judge whether we have encountered a stimulus before and to recall associated information, including where the stimulus was encountered. The perirhinal cortex (PRh) is required for judgment of stimulus familiarity, while hippocampus (HPC) and medial prefrontal cortex...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364272/ https://www.ncbi.nlm.nih.gov/pubmed/28367410 http://dx.doi.org/10.1016/j.nepig.2017.02.001 |
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author | Scott, Hannah Smith, Anna E. Barker, Gareth R. Uney, James B. Warburton, E. Clea |
author_facet | Scott, Hannah Smith, Anna E. Barker, Gareth R. Uney, James B. Warburton, E. Clea |
author_sort | Scott, Hannah |
collection | PubMed |
description | Recognition memory enables us to judge whether we have encountered a stimulus before and to recall associated information, including where the stimulus was encountered. The perirhinal cortex (PRh) is required for judgment of stimulus familiarity, while hippocampus (HPC) and medial prefrontal cortex (mPFC) are additionally involved when spatial information associated with a stimulus needs to be remembered. While gene expression is known to be essential for the consolidation of long-term recognition memory, the underlying regulatory mechanisms are not fully understood. Here we investigated the roles of two epigenetic mechanisms, DNA methylation and histone deacetylation, in recognition memory. Infusion of DNA methyltransferase inhibitors into PRh impaired performance in novel object recognition and object-in-place tasks while infusions into HPC or mPFC impaired object-in-place performance only. In contrast, inhibition of histone deacetylases in PRh, but not mPFC, enhanced recognition memory. These results support the emerging role of epigenetic processes in learning and memory. |
format | Online Article Text |
id | pubmed-5364272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-53642722017-03-31 Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory Scott, Hannah Smith, Anna E. Barker, Gareth R. Uney, James B. Warburton, E. Clea Neuroepigenetics Research Paper Recognition memory enables us to judge whether we have encountered a stimulus before and to recall associated information, including where the stimulus was encountered. The perirhinal cortex (PRh) is required for judgment of stimulus familiarity, while hippocampus (HPC) and medial prefrontal cortex (mPFC) are additionally involved when spatial information associated with a stimulus needs to be remembered. While gene expression is known to be essential for the consolidation of long-term recognition memory, the underlying regulatory mechanisms are not fully understood. Here we investigated the roles of two epigenetic mechanisms, DNA methylation and histone deacetylation, in recognition memory. Infusion of DNA methyltransferase inhibitors into PRh impaired performance in novel object recognition and object-in-place tasks while infusions into HPC or mPFC impaired object-in-place performance only. In contrast, inhibition of histone deacetylases in PRh, but not mPFC, enhanced recognition memory. These results support the emerging role of epigenetic processes in learning and memory. Elsevier Inc 2017-03-06 /pmc/articles/PMC5364272/ /pubmed/28367410 http://dx.doi.org/10.1016/j.nepig.2017.02.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Paper Scott, Hannah Smith, Anna E. Barker, Gareth R. Uney, James B. Warburton, E. Clea Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory |
title | Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory |
title_full | Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory |
title_fullStr | Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory |
title_full_unstemmed | Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory |
title_short | Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory |
title_sort | contrasting roles for dna methyltransferases and histone deacetylases in single-item and associative recognition memory |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364272/ https://www.ncbi.nlm.nih.gov/pubmed/28367410 http://dx.doi.org/10.1016/j.nepig.2017.02.001 |
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