Cargando…

The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention

INTRODUCTION: Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis. Effects of remote ischemic preconditioning (RIPC) on reperfusion injury have been investigated before, yielding conflicting results. AIM: To as...

Descripción completa

Detalles Bibliográficos
Autores principales: Yılmaztepe, Mustafa A., Taylan, Gökay, Aktoz, Meryem, Gürlertop, Hanefi Y., Aksoy, Yüksel, Özçelik, Fatih, Yalta, Kenan, Ekuklu, Galip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364281/
https://www.ncbi.nlm.nih.gov/pubmed/28344616
http://dx.doi.org/10.5114/aic.2017.66185
_version_ 1782517295253291008
author Yılmaztepe, Mustafa A.
Taylan, Gökay
Aktoz, Meryem
Gürlertop, Hanefi Y.
Aksoy, Yüksel
Özçelik, Fatih
Yalta, Kenan
Ekuklu, Galip
author_facet Yılmaztepe, Mustafa A.
Taylan, Gökay
Aktoz, Meryem
Gürlertop, Hanefi Y.
Aksoy, Yüksel
Özçelik, Fatih
Yalta, Kenan
Ekuklu, Galip
author_sort Yılmaztepe, Mustafa A.
collection PubMed
description INTRODUCTION: Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis. Effects of remote ischemic preconditioning (RIPC) on reperfusion injury have been investigated before, yielding conflicting results. AIM: To assess the impact of a single episode of RIPC on myocardial injury after elective PCI. MATERIAL AND METHODS: One hundred and four patients undergoing elective PCI, with normal baseline cardiac troponin-I (cTn-I) values, were randomized to two groups. Two patients were excluded due to data loss, and 102 patients were analyzed. Five minutes of ischemic preconditioning was delivered just before the intervention to the preconditioning group, by inflating the blood pressure cuff up to 200 mm Hg on the non-dominant arm. Postprocedural 16(th) hour cTn-I, ΔcTn-I (difference between the 16(th) h and baseline cTn-I values) and the prevalence of type 4a myocardial infarction were compared between the two groups. RESULTS: Median cTn-I values after the procedure were compared. 16(th) hour cTn-I was insignificantly lower in the preconditioning arm (0.026 μg/l vs. 0.045 μg/l, p = 0.186). The incidence of cTn-I elevation 5-fold above the upper reference limit (URL) (> 0.115 μg/l) was lower in the preconditioning group, but it was also not significant (21.6% vs. 11.8%, p = 0.184). CONCLUSIONS: A single episode of RIPC before elective PCI demonstrated less troponin elevation but failed to show a significant effect.
format Online
Article
Text
id pubmed-5364281
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-53642812017-03-24 The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention Yılmaztepe, Mustafa A. Taylan, Gökay Aktoz, Meryem Gürlertop, Hanefi Y. Aksoy, Yüksel Özçelik, Fatih Yalta, Kenan Ekuklu, Galip Postepy Kardiol Interwencyjnej Original Paper INTRODUCTION: Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis. Effects of remote ischemic preconditioning (RIPC) on reperfusion injury have been investigated before, yielding conflicting results. AIM: To assess the impact of a single episode of RIPC on myocardial injury after elective PCI. MATERIAL AND METHODS: One hundred and four patients undergoing elective PCI, with normal baseline cardiac troponin-I (cTn-I) values, were randomized to two groups. Two patients were excluded due to data loss, and 102 patients were analyzed. Five minutes of ischemic preconditioning was delivered just before the intervention to the preconditioning group, by inflating the blood pressure cuff up to 200 mm Hg on the non-dominant arm. Postprocedural 16(th) hour cTn-I, ΔcTn-I (difference between the 16(th) h and baseline cTn-I values) and the prevalence of type 4a myocardial infarction were compared between the two groups. RESULTS: Median cTn-I values after the procedure were compared. 16(th) hour cTn-I was insignificantly lower in the preconditioning arm (0.026 μg/l vs. 0.045 μg/l, p = 0.186). The incidence of cTn-I elevation 5-fold above the upper reference limit (URL) (> 0.115 μg/l) was lower in the preconditioning group, but it was also not significant (21.6% vs. 11.8%, p = 0.184). CONCLUSIONS: A single episode of RIPC before elective PCI demonstrated less troponin elevation but failed to show a significant effect. Termedia Publishing House 2017-03-10 2017 /pmc/articles/PMC5364281/ /pubmed/28344616 http://dx.doi.org/10.5114/aic.2017.66185 Text en Copyright: © 2017 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Yılmaztepe, Mustafa A.
Taylan, Gökay
Aktoz, Meryem
Gürlertop, Hanefi Y.
Aksoy, Yüksel
Özçelik, Fatih
Yalta, Kenan
Ekuklu, Galip
The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention
title The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention
title_full The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention
title_fullStr The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention
title_full_unstemmed The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention
title_short The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention
title_sort impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364281/
https://www.ncbi.nlm.nih.gov/pubmed/28344616
http://dx.doi.org/10.5114/aic.2017.66185
work_keys_str_mv AT yılmaztepemustafaa theimpactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT taylangokay theimpactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT aktozmeryem theimpactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT gurlertophanefiy theimpactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT aksoyyuksel theimpactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT ozcelikfatih theimpactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT yaltakenan theimpactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT ekuklugalip theimpactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT yılmaztepemustafaa impactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT taylangokay impactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT aktozmeryem impactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT gurlertophanefiy impactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT aksoyyuksel impactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT ozcelikfatih impactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT yaltakenan impactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention
AT ekuklugalip impactofasingleepisodeofremoteischemicpreconditioningonmyocardialinjuryafterelectivepercutaneouscoronaryintervention