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The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention
INTRODUCTION: Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis. Effects of remote ischemic preconditioning (RIPC) on reperfusion injury have been investigated before, yielding conflicting results. AIM: To as...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364281/ https://www.ncbi.nlm.nih.gov/pubmed/28344616 http://dx.doi.org/10.5114/aic.2017.66185 |
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author | Yılmaztepe, Mustafa A. Taylan, Gökay Aktoz, Meryem Gürlertop, Hanefi Y. Aksoy, Yüksel Özçelik, Fatih Yalta, Kenan Ekuklu, Galip |
author_facet | Yılmaztepe, Mustafa A. Taylan, Gökay Aktoz, Meryem Gürlertop, Hanefi Y. Aksoy, Yüksel Özçelik, Fatih Yalta, Kenan Ekuklu, Galip |
author_sort | Yılmaztepe, Mustafa A. |
collection | PubMed |
description | INTRODUCTION: Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis. Effects of remote ischemic preconditioning (RIPC) on reperfusion injury have been investigated before, yielding conflicting results. AIM: To assess the impact of a single episode of RIPC on myocardial injury after elective PCI. MATERIAL AND METHODS: One hundred and four patients undergoing elective PCI, with normal baseline cardiac troponin-I (cTn-I) values, were randomized to two groups. Two patients were excluded due to data loss, and 102 patients were analyzed. Five minutes of ischemic preconditioning was delivered just before the intervention to the preconditioning group, by inflating the blood pressure cuff up to 200 mm Hg on the non-dominant arm. Postprocedural 16(th) hour cTn-I, ΔcTn-I (difference between the 16(th) h and baseline cTn-I values) and the prevalence of type 4a myocardial infarction were compared between the two groups. RESULTS: Median cTn-I values after the procedure were compared. 16(th) hour cTn-I was insignificantly lower in the preconditioning arm (0.026 μg/l vs. 0.045 μg/l, p = 0.186). The incidence of cTn-I elevation 5-fold above the upper reference limit (URL) (> 0.115 μg/l) was lower in the preconditioning group, but it was also not significant (21.6% vs. 11.8%, p = 0.184). CONCLUSIONS: A single episode of RIPC before elective PCI demonstrated less troponin elevation but failed to show a significant effect. |
format | Online Article Text |
id | pubmed-5364281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-53642812017-03-24 The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention Yılmaztepe, Mustafa A. Taylan, Gökay Aktoz, Meryem Gürlertop, Hanefi Y. Aksoy, Yüksel Özçelik, Fatih Yalta, Kenan Ekuklu, Galip Postepy Kardiol Interwencyjnej Original Paper INTRODUCTION: Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis. Effects of remote ischemic preconditioning (RIPC) on reperfusion injury have been investigated before, yielding conflicting results. AIM: To assess the impact of a single episode of RIPC on myocardial injury after elective PCI. MATERIAL AND METHODS: One hundred and four patients undergoing elective PCI, with normal baseline cardiac troponin-I (cTn-I) values, were randomized to two groups. Two patients were excluded due to data loss, and 102 patients were analyzed. Five minutes of ischemic preconditioning was delivered just before the intervention to the preconditioning group, by inflating the blood pressure cuff up to 200 mm Hg on the non-dominant arm. Postprocedural 16(th) hour cTn-I, ΔcTn-I (difference between the 16(th) h and baseline cTn-I values) and the prevalence of type 4a myocardial infarction were compared between the two groups. RESULTS: Median cTn-I values after the procedure were compared. 16(th) hour cTn-I was insignificantly lower in the preconditioning arm (0.026 μg/l vs. 0.045 μg/l, p = 0.186). The incidence of cTn-I elevation 5-fold above the upper reference limit (URL) (> 0.115 μg/l) was lower in the preconditioning group, but it was also not significant (21.6% vs. 11.8%, p = 0.184). CONCLUSIONS: A single episode of RIPC before elective PCI demonstrated less troponin elevation but failed to show a significant effect. Termedia Publishing House 2017-03-10 2017 /pmc/articles/PMC5364281/ /pubmed/28344616 http://dx.doi.org/10.5114/aic.2017.66185 Text en Copyright: © 2017 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Yılmaztepe, Mustafa A. Taylan, Gökay Aktoz, Meryem Gürlertop, Hanefi Y. Aksoy, Yüksel Özçelik, Fatih Yalta, Kenan Ekuklu, Galip The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention |
title | The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention |
title_full | The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention |
title_fullStr | The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention |
title_full_unstemmed | The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention |
title_short | The impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention |
title_sort | impact of a single episode of remote ischemic preconditioning on myocardial injury after elective percutaneous coronary intervention |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364281/ https://www.ncbi.nlm.nih.gov/pubmed/28344616 http://dx.doi.org/10.5114/aic.2017.66185 |
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