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FMNL formins boost lamellipodial force generation

Migration frequently involves Rac-mediated protrusion of lamellipodia, formed by Arp2/3 complex-dependent branching thought to be crucial for force generation and stability of these networks. The formins FMNL2 and FMNL3 are Cdc42 effectors targeting to the lamellipodium tip and shown here to nucleat...

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Detalles Bibliográficos
Autores principales:	Kage, Frieda, Winterhoff, Moritz, Dimchev, Vanessa, Mueller, Jan, Thalheim, Tobias, Freise, Anika, Brühmann, Stefan, Kollasser, Jana, Block, Jennifer, Dimchev, Georgi, Geyer, Matthias, Schnittler, Hans-Joachim, Brakebusch, Cord, Stradal, Theresia E. B., Carlier, Marie-France, Sixt, Michael, Käs, Josef, Faix, Jan, Rottner, Klemens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364437/ https://www.ncbi.nlm.nih.gov/pubmed/28327544 http://dx.doi.org/10.1038/ncomms14832

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