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Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium

Pterygium is a very common disease in an eye clinic characterized by a benign proliferation of local conjunctiva that often crosses the limber of cornea and extends into corneal surface. Variety of studies has showed that pterygium is able to result in ocular discomfort and the change of ocular surf...

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Autores principales: Wu, Huping, Lin, Zhirong, Yang, Fan, Fang, Xie, Dong, Nuo, Luo, Shunrong, Shang, Xumin, Li, Wei, Liu, Zuguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364464/
https://www.ncbi.nlm.nih.gov/pubmed/28338041
http://dx.doi.org/10.1038/srep45115
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author Wu, Huping
Lin, Zhirong
Yang, Fan
Fang, Xie
Dong, Nuo
Luo, Shunrong
Shang, Xumin
Li, Wei
Liu, Zuguo
author_facet Wu, Huping
Lin, Zhirong
Yang, Fan
Fang, Xie
Dong, Nuo
Luo, Shunrong
Shang, Xumin
Li, Wei
Liu, Zuguo
author_sort Wu, Huping
collection PubMed
description Pterygium is a very common disease in an eye clinic characterized by a benign proliferation of local conjunctiva that often crosses the limber of cornea and extends into corneal surface. Variety of studies has showed that pterygium is able to result in ocular discomfort and the change of ocular surface environment, such as dry eye. However, the link between abnormal tear film function and pterygium is controversial. Meibomian gland dysfunction (MGD) is a common cause of dry eye and ocular discomfort but is often neglected, which may be the missing link between dry eye and pterygium. In this study, our data firstly revealed increased abnormality of meibomian gland structure and function in pterygium patients, representing with increased abnormality of MGD parameters such as meibum expression (P < 0.001) and meibomian gland loss (P < 0.001). Besides, the scores of MGD severity in patients with progressive pterygium were higher than those in patients with resting pterygium. The correlation between MGD parameters and ocular discomfort as well as dry eye indexes is also established. These findings suggest that MGD correlates to the tear film instability and ocular discomfort in patients with pterygium.
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spelling pubmed-53644642017-03-28 Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium Wu, Huping Lin, Zhirong Yang, Fan Fang, Xie Dong, Nuo Luo, Shunrong Shang, Xumin Li, Wei Liu, Zuguo Sci Rep Article Pterygium is a very common disease in an eye clinic characterized by a benign proliferation of local conjunctiva that often crosses the limber of cornea and extends into corneal surface. Variety of studies has showed that pterygium is able to result in ocular discomfort and the change of ocular surface environment, such as dry eye. However, the link between abnormal tear film function and pterygium is controversial. Meibomian gland dysfunction (MGD) is a common cause of dry eye and ocular discomfort but is often neglected, which may be the missing link between dry eye and pterygium. In this study, our data firstly revealed increased abnormality of meibomian gland structure and function in pterygium patients, representing with increased abnormality of MGD parameters such as meibum expression (P < 0.001) and meibomian gland loss (P < 0.001). Besides, the scores of MGD severity in patients with progressive pterygium were higher than those in patients with resting pterygium. The correlation between MGD parameters and ocular discomfort as well as dry eye indexes is also established. These findings suggest that MGD correlates to the tear film instability and ocular discomfort in patients with pterygium. Nature Publishing Group 2017-03-24 /pmc/articles/PMC5364464/ /pubmed/28338041 http://dx.doi.org/10.1038/srep45115 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wu, Huping
Lin, Zhirong
Yang, Fan
Fang, Xie
Dong, Nuo
Luo, Shunrong
Shang, Xumin
Li, Wei
Liu, Zuguo
Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium
title Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium
title_full Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium
title_fullStr Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium
title_full_unstemmed Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium
title_short Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium
title_sort meibomian gland dysfunction correlates to the tear film instability and ocular discomfort in patients with pterygium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364464/
https://www.ncbi.nlm.nih.gov/pubmed/28338041
http://dx.doi.org/10.1038/srep45115
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