The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downre...

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Autores principales: Kang, Hoin, Rho, Jun Gi, Kim, Chongtae, Tak, Hyosun, Lee, Heejin, Ji, Eunbyul, Ahn, Sojin, Shin, A-Ri, Cho, Hyun-Il, Huh, Yun Hyun, Song, Woo Keun, Kim, Wook, Lee, Eun Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364481/
https://www.ncbi.nlm.nih.gov/pubmed/28337997
http://dx.doi.org/10.1038/srep44847
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author Kang, Hoin
Rho, Jun Gi
Kim, Chongtae
Tak, Hyosun
Lee, Heejin
Ji, Eunbyul
Ahn, Sojin
Shin, A-Ri
Cho, Hyun-Il
Huh, Yun Hyun
Song, Woo Keun
Kim, Wook
Lee, Eun Kyung
author_facet Kang, Hoin
Rho, Jun Gi
Kim, Chongtae
Tak, Hyosun
Lee, Heejin
Ji, Eunbyul
Ahn, Sojin
Shin, A-Ri
Cho, Hyun-Il
Huh, Yun Hyun
Song, Woo Keun
Kim, Wook
Lee, Eun Kyung
author_sort Kang, Hoin
collection PubMed
description MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion.
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spelling pubmed-53644812017-03-28 The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells Kang, Hoin Rho, Jun Gi Kim, Chongtae Tak, Hyosun Lee, Heejin Ji, Eunbyul Ahn, Sojin Shin, A-Ri Cho, Hyun-Il Huh, Yun Hyun Song, Woo Keun Kim, Wook Lee, Eun Kyung Sci Rep Article MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression by suppressing translation or facilitating mRNA decay. Differential expression of miRNAs is involved in the pathogenesis of several diseases including cancer. Here, we investigated the role of-miR-24-3p as a downregulated miRNA in metastatic cancer. miR-24-3p was decreased in metastatic cancer and lower expression of miR-24-3p was related to poor survival of cancer patients. Consistently, ectopic expression of miR-24-3p suppressed the cell migration, invasion, and proliferation of MCF7, Hep3B, B16F10, SK-Hep1, and PC-3 cells by directly targeting p130Cas. Stable expression of p130Cas restored miR-24-3p-mediated inhibition of cell migration and invasion. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion. Nature Publishing Group 2017-03-24 /pmc/articles/PMC5364481/ /pubmed/28337997 http://dx.doi.org/10.1038/srep44847 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Kang, Hoin
Rho, Jun Gi
Kim, Chongtae
Tak, Hyosun
Lee, Heejin
Ji, Eunbyul
Ahn, Sojin
Shin, A-Ri
Cho, Hyun-Il
Huh, Yun Hyun
Song, Woo Keun
Kim, Wook
Lee, Eun Kyung
The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells
title The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells
title_full The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells
title_fullStr The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells
title_full_unstemmed The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells
title_short The miR-24-3p/p130Cas: a novel axis regulating the migration and invasion of cancer cells
title_sort mir-24-3p/p130cas: a novel axis regulating the migration and invasion of cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364481/
https://www.ncbi.nlm.nih.gov/pubmed/28337997
http://dx.doi.org/10.1038/srep44847
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