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Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China

BACKGROUND: There is limited data on the genotype distribution of human papillomavirus (HPV) in the Taihu River Basin, home to 1.29 million people on the coast of eastern China. This study evaluated the prevalence and genotypes among different female age groups in this region. METHODS: Twenty-six HP...

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Autores principales: Lu, Jing-fen, Shen, Guo-rong, Li, Qiong, Chen, Xu, Ma, Chun-fang, Zhu, Tong-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364703/
https://www.ncbi.nlm.nih.gov/pubmed/28335818
http://dx.doi.org/10.1186/s12879-017-2328-6
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author Lu, Jing-fen
Shen, Guo-rong
Li, Qiong
Chen, Xu
Ma, Chun-fang
Zhu, Tong-hua
author_facet Lu, Jing-fen
Shen, Guo-rong
Li, Qiong
Chen, Xu
Ma, Chun-fang
Zhu, Tong-hua
author_sort Lu, Jing-fen
collection PubMed
description BACKGROUND: There is limited data on the genotype distribution of human papillomavirus (HPV) in the Taihu River Basin, home to 1.29 million people on the coast of eastern China. This study evaluated the prevalence and genotypes among different female age groups in this region. METHODS: Twenty-six HPV strains (low-risk HPV 6, 11, 40, 42, 44, 61, 73 and high-risk HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 82, and 83) were detected using Tellgenplex™ HPV technology in samples obtained from three clinical hospitals located in different regions of the Taihu Lake Basin. RESULTS: The results showed that 1855 samples (20.97% of all samples) were found to be HPV-positive. Of these, 1375 samples (15.55% of all samples) were found to have a single HPV infection. Age-specific prevalence showed two peaks, one that corresponded to the group of 21–30 year-old women and the other peak that corresponded to the group of women over 51 years old. The three most prevalent genotypes were HPV52 (19.95%, 370/1855), HPV16 (13.48%, 150/1855), and HPV58 (11.32%, 210/1855). Mixed strains HPV58 + HPV33 and HPV58 + HPV52 were most commonly found in females infected with multiple HPV types. CONCLUSIONS: This investigation reveals that HPV infection in the Taihu River Basin varied significantly among different age groups. The most prevalent genotypes are included in the nonavalent vaccine, V503, however this vaccine is not licensed for use in mainland China. The most frequently occurring genotypes should be considered in the development of next-generation HPV vaccines for optimal protection of public health. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-017-2328-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-53647032017-03-24 Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China Lu, Jing-fen Shen, Guo-rong Li, Qiong Chen, Xu Ma, Chun-fang Zhu, Tong-hua BMC Infect Dis Research Article BACKGROUND: There is limited data on the genotype distribution of human papillomavirus (HPV) in the Taihu River Basin, home to 1.29 million people on the coast of eastern China. This study evaluated the prevalence and genotypes among different female age groups in this region. METHODS: Twenty-six HPV strains (low-risk HPV 6, 11, 40, 42, 44, 61, 73 and high-risk HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 82, and 83) were detected using Tellgenplex™ HPV technology in samples obtained from three clinical hospitals located in different regions of the Taihu Lake Basin. RESULTS: The results showed that 1855 samples (20.97% of all samples) were found to be HPV-positive. Of these, 1375 samples (15.55% of all samples) were found to have a single HPV infection. Age-specific prevalence showed two peaks, one that corresponded to the group of 21–30 year-old women and the other peak that corresponded to the group of women over 51 years old. The three most prevalent genotypes were HPV52 (19.95%, 370/1855), HPV16 (13.48%, 150/1855), and HPV58 (11.32%, 210/1855). Mixed strains HPV58 + HPV33 and HPV58 + HPV52 were most commonly found in females infected with multiple HPV types. CONCLUSIONS: This investigation reveals that HPV infection in the Taihu River Basin varied significantly among different age groups. The most prevalent genotypes are included in the nonavalent vaccine, V503, however this vaccine is not licensed for use in mainland China. The most frequently occurring genotypes should be considered in the development of next-generation HPV vaccines for optimal protection of public health. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-017-2328-6) contains supplementary material, which is available to authorized users. BioMed Central 2017-03-23 /pmc/articles/PMC5364703/ /pubmed/28335818 http://dx.doi.org/10.1186/s12879-017-2328-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Lu, Jing-fen
Shen, Guo-rong
Li, Qiong
Chen, Xu
Ma, Chun-fang
Zhu, Tong-hua
Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China
title Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China
title_full Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China
title_fullStr Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China
title_full_unstemmed Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China
title_short Genotype distribution characteristics of multiple human papillomavirus in women from the Taihu River Basin, on the coast of eastern China
title_sort genotype distribution characteristics of multiple human papillomavirus in women from the taihu river basin, on the coast of eastern china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364703/
https://www.ncbi.nlm.nih.gov/pubmed/28335818
http://dx.doi.org/10.1186/s12879-017-2328-6
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