Olanzapine overdose presenting with acute muscle toxicity

Olanzapine is an atypical antipsychotic drug that is being increasingly used as an intentional overdose. It usually presents with reduced and fluctuating level of consciousness and coma. It may rarely present with muscle toxicity by binding to HT2A receptor in skeletal muscle and increasing its perm...

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Autores principales: Keyal, Niraj, Shrestha, Gentle Sunder, Pradhan, Saurabh, Maharjan, Ramesh, Acharya, Subhash Prasad, Marhatta, Moda Nath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364771/
https://www.ncbi.nlm.nih.gov/pubmed/28382261
http://dx.doi.org/10.4103/2229-5151.201962
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author Keyal, Niraj
Shrestha, Gentle Sunder
Pradhan, Saurabh
Maharjan, Ramesh
Acharya, Subhash Prasad
Marhatta, Moda Nath
author_facet Keyal, Niraj
Shrestha, Gentle Sunder
Pradhan, Saurabh
Maharjan, Ramesh
Acharya, Subhash Prasad
Marhatta, Moda Nath
author_sort Keyal, Niraj
collection PubMed
description Olanzapine is an atypical antipsychotic drug that is being increasingly used as an intentional overdose. It usually presents with reduced and fluctuating level of consciousness and coma. It may rarely present with muscle toxicity by binding to HT2A receptor in skeletal muscle and increasing its permeability. We report a case of such poisoning which had no obvious symptoms but was brought to emergency due to overdose and was found to have acute muscle toxicity as evidenced by raised creatine phosphokinase (CPK) levels. From this, we also want to emphasize that CPK levels should be checked in all the patient's prescribed olanzapine to look for muscle toxicity.
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spelling pubmed-53647712017-04-05 Olanzapine overdose presenting with acute muscle toxicity Keyal, Niraj Shrestha, Gentle Sunder Pradhan, Saurabh Maharjan, Ramesh Acharya, Subhash Prasad Marhatta, Moda Nath Int J Crit Illn Inj Sci Case Report Olanzapine is an atypical antipsychotic drug that is being increasingly used as an intentional overdose. It usually presents with reduced and fluctuating level of consciousness and coma. It may rarely present with muscle toxicity by binding to HT2A receptor in skeletal muscle and increasing its permeability. We report a case of such poisoning which had no obvious symptoms but was brought to emergency due to overdose and was found to have acute muscle toxicity as evidenced by raised creatine phosphokinase (CPK) levels. From this, we also want to emphasize that CPK levels should be checked in all the patient's prescribed olanzapine to look for muscle toxicity. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5364771/ /pubmed/28382261 http://dx.doi.org/10.4103/2229-5151.201962 Text en Copyright: © 2017 International Journal of Critical Illness and Injury Science http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Keyal, Niraj
Shrestha, Gentle Sunder
Pradhan, Saurabh
Maharjan, Ramesh
Acharya, Subhash Prasad
Marhatta, Moda Nath
Olanzapine overdose presenting with acute muscle toxicity
title Olanzapine overdose presenting with acute muscle toxicity
title_full Olanzapine overdose presenting with acute muscle toxicity
title_fullStr Olanzapine overdose presenting with acute muscle toxicity
title_full_unstemmed Olanzapine overdose presenting with acute muscle toxicity
title_short Olanzapine overdose presenting with acute muscle toxicity
title_sort olanzapine overdose presenting with acute muscle toxicity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364771/
https://www.ncbi.nlm.nih.gov/pubmed/28382261
http://dx.doi.org/10.4103/2229-5151.201962
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