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Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy

Tumor necrosis factor (TNF) ligand related molecule 1A (TL1A), also termed TNF superfamily member 15 and vascular endothelial growth inhibitor is important for tumorigenicity and autoimmunity. However, the function of TL1A in diabetic retinopathy (DR) remains to be elucidated. The present study esta...

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Autores principales: Zhang, Zhu-Hong, Chen, Qing-Zhong, Jiang, Feng, Townsend, Todd A., Mao, Chun-Jie, You, Cai-Yun, Yang, Wen-Hui, Sun, Zhi-Yong, Yu, Jin-Guo, Yan, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364842/
https://www.ncbi.nlm.nih.gov/pubmed/28000874
http://dx.doi.org/10.3892/mmr.2016.6048
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author Zhang, Zhu-Hong
Chen, Qing-Zhong
Jiang, Feng
Townsend, Todd A.
Mao, Chun-Jie
You, Cai-Yun
Yang, Wen-Hui
Sun, Zhi-Yong
Yu, Jin-Guo
Yan, Hua
author_facet Zhang, Zhu-Hong
Chen, Qing-Zhong
Jiang, Feng
Townsend, Todd A.
Mao, Chun-Jie
You, Cai-Yun
Yang, Wen-Hui
Sun, Zhi-Yong
Yu, Jin-Guo
Yan, Hua
author_sort Zhang, Zhu-Hong
collection PubMed
description Tumor necrosis factor (TNF) ligand related molecule 1A (TL1A), also termed TNF superfamily member 15 and vascular endothelial growth inhibitor is important for tumorigenicity and autoimmunity. However, the function of TL1A in diabetic retinopathy (DR) remains to be elucidated. The present study established a diabetes mellitus (DM) rat model to investigate TL1A, vascular endothelial growth factor (VEGF), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression levels in the retina, vitreous and serum of rats with DM at different stages (1 month group, 3 month group and 6 month group). The present study determined that TL1A expression levels in the retina and vitreous from the DM 1 month group were significantly lower compared with the control group. However, TL1A levels in the retina and vitreous were significantly increased in advanced stages of DM compared with the control group. Furthermore, the levels of VEGF in the retina and vitreous were significantly higher in the DM groups compared with the control group. The expression levels of TNF-α and IL-1β in the retina and vitreous were significantly higher in DM 3 month and 6 month groups compared with the control group. It is of note that the expression levels of TL1A were significantly lower in the DM 1 and 3 month groups compared with the control group; however, they were significantly increased in the DM 6 month group compared with the DM 3 month group. The expression levels of VEGF, TNF-α and IL-1β in blood serum have been observed to exhibit similar expression change dynamics as those of the retina and vitreous. Therefore, these findings suggest that TL1A may be a protective factor of DR, and may provide a rationale for the development of novel therapeutic strategies to treat DR.
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spelling pubmed-53648422017-05-15 Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy Zhang, Zhu-Hong Chen, Qing-Zhong Jiang, Feng Townsend, Todd A. Mao, Chun-Jie You, Cai-Yun Yang, Wen-Hui Sun, Zhi-Yong Yu, Jin-Guo Yan, Hua Mol Med Rep Articles Tumor necrosis factor (TNF) ligand related molecule 1A (TL1A), also termed TNF superfamily member 15 and vascular endothelial growth inhibitor is important for tumorigenicity and autoimmunity. However, the function of TL1A in diabetic retinopathy (DR) remains to be elucidated. The present study established a diabetes mellitus (DM) rat model to investigate TL1A, vascular endothelial growth factor (VEGF), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression levels in the retina, vitreous and serum of rats with DM at different stages (1 month group, 3 month group and 6 month group). The present study determined that TL1A expression levels in the retina and vitreous from the DM 1 month group were significantly lower compared with the control group. However, TL1A levels in the retina and vitreous were significantly increased in advanced stages of DM compared with the control group. Furthermore, the levels of VEGF in the retina and vitreous were significantly higher in the DM groups compared with the control group. The expression levels of TNF-α and IL-1β in the retina and vitreous were significantly higher in DM 3 month and 6 month groups compared with the control group. It is of note that the expression levels of TL1A were significantly lower in the DM 1 and 3 month groups compared with the control group; however, they were significantly increased in the DM 6 month group compared with the DM 3 month group. The expression levels of VEGF, TNF-α and IL-1β in blood serum have been observed to exhibit similar expression change dynamics as those of the retina and vitreous. Therefore, these findings suggest that TL1A may be a protective factor of DR, and may provide a rationale for the development of novel therapeutic strategies to treat DR. D.A. Spandidos 2017-02 2016-12-14 /pmc/articles/PMC5364842/ /pubmed/28000874 http://dx.doi.org/10.3892/mmr.2016.6048 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhang, Zhu-Hong
Chen, Qing-Zhong
Jiang, Feng
Townsend, Todd A.
Mao, Chun-Jie
You, Cai-Yun
Yang, Wen-Hui
Sun, Zhi-Yong
Yu, Jin-Guo
Yan, Hua
Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy
title Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy
title_full Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy
title_fullStr Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy
title_full_unstemmed Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy
title_short Changes in TL1A levels and associated cytokines during pathogenesis of diabetic retinopathy
title_sort changes in tl1a levels and associated cytokines during pathogenesis of diabetic retinopathy
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364842/
https://www.ncbi.nlm.nih.gov/pubmed/28000874
http://dx.doi.org/10.3892/mmr.2016.6048
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