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High expression of B23 is associated with tumorigenesis and poor prognosis in bladder urothelial carcinoma
B23, a multifunctional nucleolar protein, is overexpressed in numerous cancers and is associated with tumorigenesis. However, the clinical significance and potential role of B23 in bladder urothelial carcinoma remains to be elucidated. The present study observed that the mRNA and protein expression...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364846/ https://www.ncbi.nlm.nih.gov/pubmed/27959455 http://dx.doi.org/10.3892/mmr.2016.6033 |
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author | Wang, Haiping Yuan, Gangjun Zhao, Bai Zhao, Yakun Qiu, Yu |
author_facet | Wang, Haiping Yuan, Gangjun Zhao, Bai Zhao, Yakun Qiu, Yu |
author_sort | Wang, Haiping |
collection | PubMed |
description | B23, a multifunctional nucleolar protein, is overexpressed in numerous cancers and is associated with tumorigenesis. However, the clinical significance and potential role of B23 in bladder urothelial carcinoma remains to be elucidated. The present study observed that the mRNA and protein expression levels of B23 were increased in bladder cancer cells and tissues. The overexpression of B23 contributed to tumorigenesis and was associated with poor prognosis in bladder cancer patients. Silencing of B23 by short hairpin RNA inhibited tumor cell growth and colony formation. In addition, knockdown of B23 suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), resulting in the inactivation of the ERK signaling pathway. Therefore, the present study indicated that B23 promotes bladder cancer cell growth via activation of the ERK signaling pathway and is a novel potential biomarker for the diagnosis and prognosis of bladder cancer. |
format | Online Article Text |
id | pubmed-5364846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-53648462017-05-15 High expression of B23 is associated with tumorigenesis and poor prognosis in bladder urothelial carcinoma Wang, Haiping Yuan, Gangjun Zhao, Bai Zhao, Yakun Qiu, Yu Mol Med Rep Articles B23, a multifunctional nucleolar protein, is overexpressed in numerous cancers and is associated with tumorigenesis. However, the clinical significance and potential role of B23 in bladder urothelial carcinoma remains to be elucidated. The present study observed that the mRNA and protein expression levels of B23 were increased in bladder cancer cells and tissues. The overexpression of B23 contributed to tumorigenesis and was associated with poor prognosis in bladder cancer patients. Silencing of B23 by short hairpin RNA inhibited tumor cell growth and colony formation. In addition, knockdown of B23 suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), resulting in the inactivation of the ERK signaling pathway. Therefore, the present study indicated that B23 promotes bladder cancer cell growth via activation of the ERK signaling pathway and is a novel potential biomarker for the diagnosis and prognosis of bladder cancer. D.A. Spandidos 2017-02 2016-12-13 /pmc/articles/PMC5364846/ /pubmed/27959455 http://dx.doi.org/10.3892/mmr.2016.6033 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Wang, Haiping Yuan, Gangjun Zhao, Bai Zhao, Yakun Qiu, Yu High expression of B23 is associated with tumorigenesis and poor prognosis in bladder urothelial carcinoma |
title | High expression of B23 is associated with tumorigenesis and poor prognosis in bladder urothelial carcinoma |
title_full | High expression of B23 is associated with tumorigenesis and poor prognosis in bladder urothelial carcinoma |
title_fullStr | High expression of B23 is associated with tumorigenesis and poor prognosis in bladder urothelial carcinoma |
title_full_unstemmed | High expression of B23 is associated with tumorigenesis and poor prognosis in bladder urothelial carcinoma |
title_short | High expression of B23 is associated with tumorigenesis and poor prognosis in bladder urothelial carcinoma |
title_sort | high expression of b23 is associated with tumorigenesis and poor prognosis in bladder urothelial carcinoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364846/ https://www.ncbi.nlm.nih.gov/pubmed/27959455 http://dx.doi.org/10.3892/mmr.2016.6033 |
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