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Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of rapamycin pathway dephosphorylation

Decreased autophagy is accompanied by the development of a myeloproliferative state or acute myeloid leukemia (AML). AML cells are often sensitive to autophagy-inducing stimuli, prompting the idea that targeting autophagy can be useful in AML cytotoxic therapy. AML NB4 cells overexpressing microtubu...

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Detalles Bibliográficos
Autores principales:	Tao, Yan-Fang, Li, Zhi-Heng, Du, Wei-Wei, Xu, Li-Xiao, Ren, Jun-Li, Li, Xiao-Lu, Fang, Fang, Xie, Yi, Li, Mei, Qian, Guang-Hui, Li, Yan-Hong, Li, Yi-Ping, Li, Gang, Wu, Yi, Feng, Xing, Wang, Jian, He, Wei-Qi, Hu, Shao-Yan, Lu, Jun, Pan, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364848/ https://www.ncbi.nlm.nih.gov/pubmed/28184925 http://dx.doi.org/10.3892/or.2017.5417

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