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Downregulation of the β1 adrenergic receptor in the myocardium results in insensitivity to metoprolol and reduces blood pressure in spontaneously hypertensive rats

The β1-adrenergic receptor (AR) is the primary β-AR subtype in the heart and is the target of metoprolol (Met), which is commonly used to treat angina and hypertension. Previous studies have revealed a positive correlation between the methylation levels of the adrenoreceptor β1 gene (Adrb1) promoter...

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Detalles Bibliográficos
Autores principales:	Huang, Yun, Liu, Xiao-Li, Wen, Jia, Huang, Li-Hua, Lu, Yao, Miao, Ru-Jia, Liu, Xing, Li, Ying, Xing, Xiao-Wei, Yuan, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364866/ https://www.ncbi.nlm.nih.gov/pubmed/28000860 http://dx.doi.org/10.3892/mmr.2016.6038

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