Construction and verification of CYP3A5 gene polymorphisms using a Saccharomyces cerevisiae expression system to predict drug metabolism

The present study evaluated the ability of a Saccharomyces cerevisiae expression system to predict the pharmacokinetic (PK) activity of a calcium channel blocker in patients with distinct cytochrome P450 3A5 (CYP3A5) polymorphisms. The blood pressure lowering activity of amlodipine in 57 hypertensiv...

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Detalles Bibliográficos
Autores principales: Lu, Yao, Zhong, Hua, Tang, Qing, Huang, Zhijun, Jing, Ningning, Smith, Julie, Miao, Rujia, Li, Yapei, Yuan, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364972/
https://www.ncbi.nlm.nih.gov/pubmed/28259948
http://dx.doi.org/10.3892/mmr.2017.6214

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