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Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation
At present, data on the endocannabinoid system expression and distribution in the pancreatic gland appear scarce and controversial as descriptions are limited to humans and laboratory animals. Since the bovine pancreas is very similar to the human in endocrine portion development and control, studie...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364978/ https://www.ncbi.nlm.nih.gov/pubmed/28348424 http://dx.doi.org/10.4081/ejh.2017.2761 |
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author | Dall’Aglio, Cecilia Polisca, Angela Cappai, Maria Grazia Mercati, Francesca Troisi, Alessandro Pirino, Carolina Scocco, Paola Maranesi, Margherita |
author_facet | Dall’Aglio, Cecilia Polisca, Angela Cappai, Maria Grazia Mercati, Francesca Troisi, Alessandro Pirino, Carolina Scocco, Paola Maranesi, Margherita |
author_sort | Dall’Aglio, Cecilia |
collection | PubMed |
description | At present, data on the endocannabinoid system expression and distribution in the pancreatic gland appear scarce and controversial as descriptions are limited to humans and laboratory animals. Since the bovine pancreas is very similar to the human in endocrine portion development and control, studies on the fetal gland could prove to be very interesting, as an abnormal maternal condition during late pregnancy may be a predisposing trigger for adult metabolic disorders. The present investigation studied cannabinoid receptor type 2 presence and distribution in the bovine fetal pancreas towards the end of gestation. Histological analyses revealed numerous endocrinal cell clusters or islets which were distributed among exocrine adenomeri in connectival tissue. Immunohistochemistry showed that endocrine-islets contained some CB2-positive cells with a very peculiar localization that is a few primarily localized at the edges of islets and some of them also scattered in the center of the cluster. Characteristically, also the epithelium of the excretory ducts and the smooth muscle layers of the smaller arteries, in the interlobular glandular septa, tested positive for the CB2 endocannabinoid receptor. Consequently, the endocannabinoid system, via the cannabinoid receptor type 2, was hypothesized to play a major role in controlling pancreas function from normal fetal development to correct metabolic functioning in adulthood. |
format | Online Article Text |
id | pubmed-5364978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-53649782017-04-05 Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation Dall’Aglio, Cecilia Polisca, Angela Cappai, Maria Grazia Mercati, Francesca Troisi, Alessandro Pirino, Carolina Scocco, Paola Maranesi, Margherita Eur J Histochem Brief Report At present, data on the endocannabinoid system expression and distribution in the pancreatic gland appear scarce and controversial as descriptions are limited to humans and laboratory animals. Since the bovine pancreas is very similar to the human in endocrine portion development and control, studies on the fetal gland could prove to be very interesting, as an abnormal maternal condition during late pregnancy may be a predisposing trigger for adult metabolic disorders. The present investigation studied cannabinoid receptor type 2 presence and distribution in the bovine fetal pancreas towards the end of gestation. Histological analyses revealed numerous endocrinal cell clusters or islets which were distributed among exocrine adenomeri in connectival tissue. Immunohistochemistry showed that endocrine-islets contained some CB2-positive cells with a very peculiar localization that is a few primarily localized at the edges of islets and some of them also scattered in the center of the cluster. Characteristically, also the epithelium of the excretory ducts and the smooth muscle layers of the smaller arteries, in the interlobular glandular septa, tested positive for the CB2 endocannabinoid receptor. Consequently, the endocannabinoid system, via the cannabinoid receptor type 2, was hypothesized to play a major role in controlling pancreas function from normal fetal development to correct metabolic functioning in adulthood. PAGEPress Publications, Pavia, Italy 2017-03-07 /pmc/articles/PMC5364978/ /pubmed/28348424 http://dx.doi.org/10.4081/ejh.2017.2761 Text en ©Copyright C. Dall’Aglio et al., 2017 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Dall’Aglio, Cecilia Polisca, Angela Cappai, Maria Grazia Mercati, Francesca Troisi, Alessandro Pirino, Carolina Scocco, Paola Maranesi, Margherita Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation |
title | Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation |
title_full | Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation |
title_fullStr | Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation |
title_full_unstemmed | Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation |
title_short | Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation |
title_sort | immunohistochemistry detected and localized cannabinoid receptor type 2 in bovine fetal pancreas at late gestation |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364978/ https://www.ncbi.nlm.nih.gov/pubmed/28348424 http://dx.doi.org/10.4081/ejh.2017.2761 |
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