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Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation

At present, data on the endocannabinoid system expression and distribution in the pancreatic gland appear scarce and controversial as descriptions are limited to humans and laboratory animals. Since the bovine pancreas is very similar to the human in endocrine portion development and control, studie...

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Autores principales: Dall’Aglio, Cecilia, Polisca, Angela, Cappai, Maria Grazia, Mercati, Francesca, Troisi, Alessandro, Pirino, Carolina, Scocco, Paola, Maranesi, Margherita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364978/
https://www.ncbi.nlm.nih.gov/pubmed/28348424
http://dx.doi.org/10.4081/ejh.2017.2761
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author Dall’Aglio, Cecilia
Polisca, Angela
Cappai, Maria Grazia
Mercati, Francesca
Troisi, Alessandro
Pirino, Carolina
Scocco, Paola
Maranesi, Margherita
author_facet Dall’Aglio, Cecilia
Polisca, Angela
Cappai, Maria Grazia
Mercati, Francesca
Troisi, Alessandro
Pirino, Carolina
Scocco, Paola
Maranesi, Margherita
author_sort Dall’Aglio, Cecilia
collection PubMed
description At present, data on the endocannabinoid system expression and distribution in the pancreatic gland appear scarce and controversial as descriptions are limited to humans and laboratory animals. Since the bovine pancreas is very similar to the human in endocrine portion development and control, studies on the fetal gland could prove to be very interesting, as an abnormal maternal condition during late pregnancy may be a predisposing trigger for adult metabolic disorders. The present investigation studied cannabinoid receptor type 2 presence and distribution in the bovine fetal pancreas towards the end of gestation. Histological analyses revealed numerous endocrinal cell clusters or islets which were distributed among exocrine adenomeri in connectival tissue. Immunohistochemistry showed that endocrine-islets contained some CB2-positive cells with a very peculiar localization that is a few primarily localized at the edges of islets and some of them also scattered in the center of the cluster. Characteristically, also the epithelium of the excretory ducts and the smooth muscle layers of the smaller arteries, in the interlobular glandular septa, tested positive for the CB2 endocannabinoid receptor. Consequently, the endocannabinoid system, via the cannabinoid receptor type 2, was hypothesized to play a major role in controlling pancreas function from normal fetal development to correct metabolic functioning in adulthood.
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spelling pubmed-53649782017-04-05 Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation Dall’Aglio, Cecilia Polisca, Angela Cappai, Maria Grazia Mercati, Francesca Troisi, Alessandro Pirino, Carolina Scocco, Paola Maranesi, Margherita Eur J Histochem Brief Report At present, data on the endocannabinoid system expression and distribution in the pancreatic gland appear scarce and controversial as descriptions are limited to humans and laboratory animals. Since the bovine pancreas is very similar to the human in endocrine portion development and control, studies on the fetal gland could prove to be very interesting, as an abnormal maternal condition during late pregnancy may be a predisposing trigger for adult metabolic disorders. The present investigation studied cannabinoid receptor type 2 presence and distribution in the bovine fetal pancreas towards the end of gestation. Histological analyses revealed numerous endocrinal cell clusters or islets which were distributed among exocrine adenomeri in connectival tissue. Immunohistochemistry showed that endocrine-islets contained some CB2-positive cells with a very peculiar localization that is a few primarily localized at the edges of islets and some of them also scattered in the center of the cluster. Characteristically, also the epithelium of the excretory ducts and the smooth muscle layers of the smaller arteries, in the interlobular glandular septa, tested positive for the CB2 endocannabinoid receptor. Consequently, the endocannabinoid system, via the cannabinoid receptor type 2, was hypothesized to play a major role in controlling pancreas function from normal fetal development to correct metabolic functioning in adulthood. PAGEPress Publications, Pavia, Italy 2017-03-07 /pmc/articles/PMC5364978/ /pubmed/28348424 http://dx.doi.org/10.4081/ejh.2017.2761 Text en ©Copyright C. Dall’Aglio et al., 2017 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Dall’Aglio, Cecilia
Polisca, Angela
Cappai, Maria Grazia
Mercati, Francesca
Troisi, Alessandro
Pirino, Carolina
Scocco, Paola
Maranesi, Margherita
Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation
title Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation
title_full Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation
title_fullStr Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation
title_full_unstemmed Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation
title_short Immunohistochemistry Detected and Localized Cannabinoid Receptor Type 2 in Bovine Fetal Pancreas at Late Gestation
title_sort immunohistochemistry detected and localized cannabinoid receptor type 2 in bovine fetal pancreas at late gestation
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364978/
https://www.ncbi.nlm.nih.gov/pubmed/28348424
http://dx.doi.org/10.4081/ejh.2017.2761
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