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Apoptosis-independent cleavage of RhoGDIβ at Asp19 during PMA-stimulated differentiation of THP-1 cells to macrophages

Rho GDP-dissociation inhibitor β (RhoGDIβ), a regulator of the Rho family of proteins, is expressed abundantly in the hematopoietic cell lineage. During apoptosis of hematopoietic cells, RhoGDIβ is cleaved by caspase-3 at Asp19 and this cleaved form (Δ19-RhoGDIβ) has been implicated in the apoptotic...

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Detalles Bibliográficos
Autores principales:	Ota, Takahide, Jiang, Yong-Sheng, Fujiwara, Mamoru, Tatsuka, Masaaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365007/ https://www.ncbi.nlm.nih.gov/pubmed/28260067 http://dx.doi.org/10.3892/mmr.2017.6199

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