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Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis
Actinobacteria produce a variety of polyketide alkaloids with unusual structures. Recently, it was shown that a type I modular polyketide synthase (PKS) is involved in the assembly of coelimycin P1, a polyketide alkaloid produced by Streptomyces coelicolor M145. However, the mechanisms for convertin...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365063/ https://www.ncbi.nlm.nih.gov/pubmed/28451186 http://dx.doi.org/10.1039/c6sc02803a |