Dimethyl fumarate–induced lymphopenia in MS due to differential T-cell subset apoptosis

OBJECTIVE: To examine the mechanism underlying the preferential CD8(+) vs CD4(+) T-cell lymphopenia induced by dimethyl fumarate (DMF) treatment of MS. METHODS: Total lymphocyte counts and comprehensive T-cell subset analyses were performed in high-quality samples obtained from patients with MS prio...

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Detalles Bibliográficos
Autores principales: Ghadiri, Mahtab, Rezk, Ayman, Li, Rui, Evans, Ashley, Luessi, Felix, Zipp, Frauke, Giacomini, Paul S., Antel, Jack, Bar-Or, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365096/
https://www.ncbi.nlm.nih.gov/pubmed/28377940
http://dx.doi.org/10.1212/NXI.0000000000000340

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