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Effect of vitamin D(3)-supplementation on bone markers (serum P1NP and CTX): A randomized, double blinded, placebo controlled trial among healthy immigrants living in Norway

OBJECTIVE: Vitamin D is essential for the maintenance of calcium homeostasis and bone mineralization; and low serum 25-hydroxyvitamin D (s-25-(OH)D) concentrations are associated with increased bone turnover. However, there is a lack of randomized controlled trials that have investigated the effect...

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Autores principales: Madar, Ahmed A., Knutsen, Kirsten V., Stene, Lars C., Brekke, Mette, Lagerløv, Per, Meyer, Haakon E., Macdonald, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365165/
https://www.ncbi.nlm.nih.gov/pubmed/28377958
http://dx.doi.org/10.1016/j.bonr.2015.05.004
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author Madar, Ahmed A.
Knutsen, Kirsten V.
Stene, Lars C.
Brekke, Mette
Lagerløv, Per
Meyer, Haakon E.
Macdonald, Helen M.
author_facet Madar, Ahmed A.
Knutsen, Kirsten V.
Stene, Lars C.
Brekke, Mette
Lagerløv, Per
Meyer, Haakon E.
Macdonald, Helen M.
author_sort Madar, Ahmed A.
collection PubMed
description OBJECTIVE: Vitamin D is essential for the maintenance of calcium homeostasis and bone mineralization; and low serum 25-hydroxyvitamin D (s-25-(OH)D) concentrations are associated with increased bone turnover. However, there is a lack of randomized controlled trials that have investigated the effect of vitamin D treatment on bone turnover in immigrant populations. We aimed to investigate the effect of 16-week daily vitamin D(3) supplementation on bone formation marker serum procollagen type 1 amino-terminal propeptide (P1NP) and bone resorption marker C-terminal crosslinked telopeptide of type I collagen (CTX). DESIGN: Double-blind, randomized, placebo-controlled trial. SETTING: Immigrant community centers in Oslo, Norway. PARTICIPANTS: 251 healthy adults aged 18–50 years with a non-Western immigrant background were recruited. INTERVENTION: 16 weeks of daily oral supplementation with either 10 μg vitamin D(3), 25 μg vitamin D(3), or placebo. MAIN OUTCOME MEASURES: Difference in change during the 16-week intervention between the intervention groups combined (10 or 25 μg of vitamin D(3)/day) and placebo, in serum P1NP and serum CTX. RESULTS: A total of 214 (85%) participants completed the study. S-25-(OH)D increased from 29 nmol/L at baseline to 49 nmol/L in the intervention group with no significant change in the placebo group. However, there was no difference in change of serum P1NP (mean difference: − 1.2 μg/L (95% CI: − 5.4, 2.9, P = 0.6)) and serum CTX (mean difference: − 0.005 μg/L (95% CI: − 0.03, 0.02, P = 0.7)) between those receiving vitamin D(3) supplementation compared with placebo. The plasma PTH had decreased by a mean of − 1.97 pmol/L (95% CI: − 2.7, − 1.3, P < 0.0001) in the vitamin D(3) group compared to placebo. CONCLUSIONS: Supplementation with 10 or 25 μg oral vitamin D(3) during winter and spring for 16 weeks did not significantly affect serum P1NP and serum CTX, despite increasing s-25(OH)D and decreasing PTH in a healthy immigrant population with low baseline vitamin D status. Trial registration number: NCT01263288.
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spelling pubmed-53651652017-04-04 Effect of vitamin D(3)-supplementation on bone markers (serum P1NP and CTX): A randomized, double blinded, placebo controlled trial among healthy immigrants living in Norway Madar, Ahmed A. Knutsen, Kirsten V. Stene, Lars C. Brekke, Mette Lagerløv, Per Meyer, Haakon E. Macdonald, Helen M. Bone Rep Article OBJECTIVE: Vitamin D is essential for the maintenance of calcium homeostasis and bone mineralization; and low serum 25-hydroxyvitamin D (s-25-(OH)D) concentrations are associated with increased bone turnover. However, there is a lack of randomized controlled trials that have investigated the effect of vitamin D treatment on bone turnover in immigrant populations. We aimed to investigate the effect of 16-week daily vitamin D(3) supplementation on bone formation marker serum procollagen type 1 amino-terminal propeptide (P1NP) and bone resorption marker C-terminal crosslinked telopeptide of type I collagen (CTX). DESIGN: Double-blind, randomized, placebo-controlled trial. SETTING: Immigrant community centers in Oslo, Norway. PARTICIPANTS: 251 healthy adults aged 18–50 years with a non-Western immigrant background were recruited. INTERVENTION: 16 weeks of daily oral supplementation with either 10 μg vitamin D(3), 25 μg vitamin D(3), or placebo. MAIN OUTCOME MEASURES: Difference in change during the 16-week intervention between the intervention groups combined (10 or 25 μg of vitamin D(3)/day) and placebo, in serum P1NP and serum CTX. RESULTS: A total of 214 (85%) participants completed the study. S-25-(OH)D increased from 29 nmol/L at baseline to 49 nmol/L in the intervention group with no significant change in the placebo group. However, there was no difference in change of serum P1NP (mean difference: − 1.2 μg/L (95% CI: − 5.4, 2.9, P = 0.6)) and serum CTX (mean difference: − 0.005 μg/L (95% CI: − 0.03, 0.02, P = 0.7)) between those receiving vitamin D(3) supplementation compared with placebo. The plasma PTH had decreased by a mean of − 1.97 pmol/L (95% CI: − 2.7, − 1.3, P < 0.0001) in the vitamin D(3) group compared to placebo. CONCLUSIONS: Supplementation with 10 or 25 μg oral vitamin D(3) during winter and spring for 16 weeks did not significantly affect serum P1NP and serum CTX, despite increasing s-25(OH)D and decreasing PTH in a healthy immigrant population with low baseline vitamin D status. Trial registration number: NCT01263288. Elsevier 2015-05-21 /pmc/articles/PMC5365165/ /pubmed/28377958 http://dx.doi.org/10.1016/j.bonr.2015.05.004 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Madar, Ahmed A.
Knutsen, Kirsten V.
Stene, Lars C.
Brekke, Mette
Lagerløv, Per
Meyer, Haakon E.
Macdonald, Helen M.
Effect of vitamin D(3)-supplementation on bone markers (serum P1NP and CTX): A randomized, double blinded, placebo controlled trial among healthy immigrants living in Norway
title Effect of vitamin D(3)-supplementation on bone markers (serum P1NP and CTX): A randomized, double blinded, placebo controlled trial among healthy immigrants living in Norway
title_full Effect of vitamin D(3)-supplementation on bone markers (serum P1NP and CTX): A randomized, double blinded, placebo controlled trial among healthy immigrants living in Norway
title_fullStr Effect of vitamin D(3)-supplementation on bone markers (serum P1NP and CTX): A randomized, double blinded, placebo controlled trial among healthy immigrants living in Norway
title_full_unstemmed Effect of vitamin D(3)-supplementation on bone markers (serum P1NP and CTX): A randomized, double blinded, placebo controlled trial among healthy immigrants living in Norway
title_short Effect of vitamin D(3)-supplementation on bone markers (serum P1NP and CTX): A randomized, double blinded, placebo controlled trial among healthy immigrants living in Norway
title_sort effect of vitamin d(3)-supplementation on bone markers (serum p1np and ctx): a randomized, double blinded, placebo controlled trial among healthy immigrants living in norway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365165/
https://www.ncbi.nlm.nih.gov/pubmed/28377958
http://dx.doi.org/10.1016/j.bonr.2015.05.004
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