Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1

Tethered enzymatic reactions are ubiquitous in signaling networks but are poorly understood. A previously unreported mathematical analysis is established for tethered signaling reactions in surface plasmon resonance (SPR). Applying the method to the phosphatase SHP-1 interacting with a phosphorylate...

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Detalles Bibliográficos
Autores principales: Goyette, Jesse, Salas, Citlali Solis, Coker-Gordon, Nicola, Bridge, Marcus, Isaacson, Samuel A., Allard, Jun, Dushek, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365251/
https://www.ncbi.nlm.nih.gov/pubmed/28378014
http://dx.doi.org/10.1126/sciadv.1601692

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