Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays

In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mu...

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Detalles Bibliográficos
Autores principales: Ajileye, Adebisi, Alvarez, Nataly, Merker, Matthias, Walker, Timothy M., Akter, Suriya, Brown, Kerstin, Moradigaravand, Danesh, Schön, Thomas, Andres, Sönke, Schleusener, Viola, Omar, Shaheed V., Coll, Francesc, Huang, Hairong, Diel, Roland, Ismail, Nazir, Parkhill, Julian, de Jong, Bouke C., Peto, Tim E. A., Crook, Derrick W., Niemann, Stefan, Robledo, Jaime, Smith, E. Grace, Peacock, Sharon J., Köser, Claudio U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365657/
https://www.ncbi.nlm.nih.gov/pubmed/28137812
http://dx.doi.org/10.1128/AAC.02169-16

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