Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays

In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mu...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Ajileye, Adebisi, Alvarez, Nataly, Merker, Matthias, Walker, Timothy M., Akter, Suriya, Brown, Kerstin, Moradigaravand, Danesh, Schön, Thomas, Andres, Sönke, Schleusener, Viola, Omar, Shaheed V., Coll, Francesc, Huang, Hairong, Diel, Roland, Ismail, Nazir, Parkhill, Julian, de Jong, Bouke C., Peto, Tim E. A., Crook, Derrick W., Niemann, Stefan, Robledo, Jaime, Smith, E. Grace, Peacock, Sharon J., Köser, Claudio U.
Formáid: Online Alt Téacs
Teanga:English
Foilsithe / Cruthaithe: American Society for Microbiology 2017
Ábhair:
Mechanisms of Resistance
Rochtain ar líne:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365657/
https://www.ncbi.nlm.nih.gov/pubmed/28137812
http://dx.doi.org/10.1128/AAC.02169-16

Ar líne

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365657/
https://www.ncbi.nlm.nih.gov/pubmed/28137812
http://dx.doi.org/10.1128/AAC.02169-16

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