Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro

A number of inhibitors of the essential Mycobacterium tuberculosis mycolic acid transporter, MmpL3, are currently under development as potential novel antituberculosis agents. Using the checkerboard method to study the interaction profiles of various antituberculosis drugs or experimental compounds...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Wei, Sanchez-Hidalgo, Andrea, Jones, Victoria, de Moura, Vinicius Calado Nogueira, North, E. Jeffrey, Jackson, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Susceptibility
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365669/
https://www.ncbi.nlm.nih.gov/pubmed/28115355
http://dx.doi.org/10.1128/AAC.02399-16
_version_ 1782517511817789440
author Li, Wei
Sanchez-Hidalgo, Andrea
Jones, Victoria
de Moura, Vinicius Calado Nogueira
North, E. Jeffrey
Jackson, Mary
author_facet Li, Wei
Sanchez-Hidalgo, Andrea
Jones, Victoria
de Moura, Vinicius Calado Nogueira
North, E. Jeffrey
Jackson, Mary
author_sort Li, Wei
collection PubMed
description A number of inhibitors of the essential Mycobacterium tuberculosis mycolic acid transporter, MmpL3, are currently under development as potential novel antituberculosis agents. Using the checkerboard method to study the interaction profiles of various antituberculosis drugs or experimental compounds with two different chemotypes inhibiting this transporter (indolcarboxamides and adamantyl ureas), we showed that MmpL3 inhibitors act synergistically with rifampin, bedaquiline, clofazimine, and β-lactams.
format Online
Article
Text
id pubmed-5365669
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-53656692017-04-12 Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro Li, Wei Sanchez-Hidalgo, Andrea Jones, Victoria de Moura, Vinicius Calado Nogueira North, E. Jeffrey Jackson, Mary Antimicrob Agents Chemother Susceptibility A number of inhibitors of the essential Mycobacterium tuberculosis mycolic acid transporter, MmpL3, are currently under development as potential novel antituberculosis agents. Using the checkerboard method to study the interaction profiles of various antituberculosis drugs or experimental compounds with two different chemotypes inhibiting this transporter (indolcarboxamides and adamantyl ureas), we showed that MmpL3 inhibitors act synergistically with rifampin, bedaquiline, clofazimine, and β-lactams. American Society for Microbiology 2017-03-24 /pmc/articles/PMC5365669/ /pubmed/28115355 http://dx.doi.org/10.1128/AAC.02399-16 Text en Copyright © 2017 Li et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Susceptibility
Li, Wei
Sanchez-Hidalgo, Andrea
Jones, Victoria
de Moura, Vinicius Calado Nogueira
North, E. Jeffrey
Jackson, Mary
Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro
title Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro
title_full Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro
title_fullStr Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro
title_full_unstemmed Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro
title_short Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro
title_sort synergistic interactions of mmpl3 inhibitors with antitubercular compounds in vitro
topic Susceptibility
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365669/
https://www.ncbi.nlm.nih.gov/pubmed/28115355
http://dx.doi.org/10.1128/AAC.02399-16
work_keys_str_mv AT liwei synergisticinteractionsofmmpl3inhibitorswithantitubercularcompoundsinvitro
AT sanchezhidalgoandrea synergisticinteractionsofmmpl3inhibitorswithantitubercularcompoundsinvitro
AT jonesvictoria synergisticinteractionsofmmpl3inhibitorswithantitubercularcompoundsinvitro
AT demouraviniciuscaladonogueira synergisticinteractionsofmmpl3inhibitorswithantitubercularcompoundsinvitro
AT northejeffrey synergisticinteractionsofmmpl3inhibitorswithantitubercularcompoundsinvitro
AT jacksonmary synergisticinteractionsofmmpl3inhibitorswithantitubercularcompoundsinvitro

Ejemplares similares