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The contribution of dietary restriction to extended longevity in the malaria vector Anopheles coluzzii

BACKGROUND: Variation in longevity has long been of interest in vector biology because of its implication in disease transmission through vectorial capacity. Recent studies suggest that Anopheles coluzzii adults persist during the ~7 month dry season via aestivation. Recently there has been a growin...

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Autores principales: Faiman, Roy, Solon-Biet, Samantha, Sullivan, Margery, Huestis, Diana L., Lehmann, Tovi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366120/
https://www.ncbi.nlm.nih.gov/pubmed/28340627
http://dx.doi.org/10.1186/s13071-017-2088-6
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author Faiman, Roy
Solon-Biet, Samantha
Sullivan, Margery
Huestis, Diana L.
Lehmann, Tovi
author_facet Faiman, Roy
Solon-Biet, Samantha
Sullivan, Margery
Huestis, Diana L.
Lehmann, Tovi
author_sort Faiman, Roy
collection PubMed
description BACKGROUND: Variation in longevity has long been of interest in vector biology because of its implication in disease transmission through vectorial capacity. Recent studies suggest that Anopheles coluzzii adults persist during the ~7 month dry season via aestivation. Recently there has been a growing body of evidence linking dietary restriction and low ratio of dietary protein to carbohydrate with extended longevity of animals. Here, we evaluated the effects of dietary restriction and the protein : carbohydrate ratio on longevity of An. coluzzii. RESULTS: In our experiment, we combined dietary regimes with temperature and relative humidity to assess their effects on An. coluzzii longevity, in an attempt to simulate aestivation under laboratory conditions. Our results showed significant effects of both the physical and the dietary variables on longevity, but that diet regimen had a considerably greater effect than those of the physical conditions. Higher temperature and lower humidity reduced longevity. At 22 °C dietary protein (blood) shortened longevity when sugar was not restricted (RH = 85%), but extended longevity when sugar was restricted (RH = 50%). CONCLUSIONS: Dietary restriction extended longevity in accord with predictions, but protein : carbohydrate ratio had a negligible effect. We identified conditions that significantly extend longevity in malaria vectors, however, the extent of increase in longevity was insufficient to simulate aestivation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-017-2088-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-53661202017-03-28 The contribution of dietary restriction to extended longevity in the malaria vector Anopheles coluzzii Faiman, Roy Solon-Biet, Samantha Sullivan, Margery Huestis, Diana L. Lehmann, Tovi Parasit Vectors Research BACKGROUND: Variation in longevity has long been of interest in vector biology because of its implication in disease transmission through vectorial capacity. Recent studies suggest that Anopheles coluzzii adults persist during the ~7 month dry season via aestivation. Recently there has been a growing body of evidence linking dietary restriction and low ratio of dietary protein to carbohydrate with extended longevity of animals. Here, we evaluated the effects of dietary restriction and the protein : carbohydrate ratio on longevity of An. coluzzii. RESULTS: In our experiment, we combined dietary regimes with temperature and relative humidity to assess their effects on An. coluzzii longevity, in an attempt to simulate aestivation under laboratory conditions. Our results showed significant effects of both the physical and the dietary variables on longevity, but that diet regimen had a considerably greater effect than those of the physical conditions. Higher temperature and lower humidity reduced longevity. At 22 °C dietary protein (blood) shortened longevity when sugar was not restricted (RH = 85%), but extended longevity when sugar was restricted (RH = 50%). CONCLUSIONS: Dietary restriction extended longevity in accord with predictions, but protein : carbohydrate ratio had a negligible effect. We identified conditions that significantly extend longevity in malaria vectors, however, the extent of increase in longevity was insufficient to simulate aestivation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-017-2088-6) contains supplementary material, which is available to authorized users. BioMed Central 2017-03-24 /pmc/articles/PMC5366120/ /pubmed/28340627 http://dx.doi.org/10.1186/s13071-017-2088-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Faiman, Roy
Solon-Biet, Samantha
Sullivan, Margery
Huestis, Diana L.
Lehmann, Tovi
The contribution of dietary restriction to extended longevity in the malaria vector Anopheles coluzzii
title The contribution of dietary restriction to extended longevity in the malaria vector Anopheles coluzzii
title_full The contribution of dietary restriction to extended longevity in the malaria vector Anopheles coluzzii
title_fullStr The contribution of dietary restriction to extended longevity in the malaria vector Anopheles coluzzii
title_full_unstemmed The contribution of dietary restriction to extended longevity in the malaria vector Anopheles coluzzii
title_short The contribution of dietary restriction to extended longevity in the malaria vector Anopheles coluzzii
title_sort contribution of dietary restriction to extended longevity in the malaria vector anopheles coluzzii
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366120/
https://www.ncbi.nlm.nih.gov/pubmed/28340627
http://dx.doi.org/10.1186/s13071-017-2088-6
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