NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury

BACKGROUND: NADPH oxidase (NOX2) is an enzyme system that generates reactive oxygen species (ROS) in microglia and macrophages. Excessive ROS production is linked with neuroinflammation and chronic neurodegeneration following traumatic brain injury (TBI). Redox signaling regulates macrophage/microgl...

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Detalles Bibliográficos
Autores principales: Barrett, James P., Henry, Rebecca J., Villapol, Sonia, Stoica, Bogdan A., Kumar, Alok, Burns, Mark P., Faden, Alan I., Loane, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366128/
https://www.ncbi.nlm.nih.gov/pubmed/28340575
http://dx.doi.org/10.1186/s12974-017-0843-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366128/
https://www.ncbi.nlm.nih.gov/pubmed/28340575
http://dx.doi.org/10.1186/s12974-017-0843-4

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