Cargando…

Comparison of angle, shape, and position of articular processes in Dobermans and Great Danes with and without cervical spondylomyelopathy

BACKGROUND: Cervical spondylomyelopathy (CSM), also known as wobbler syndrome, affects mainly large and giant-breed dogs, causing compression of the cervical spinal cord and/or nerve roots. Structural and dynamic components seem to play a role in the development of CSM; however, pathogenesis is not...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonelli, Marília de Albuquerque, da Costa, Ronaldo Casimiro, Martin-Vaquero, Paula, Lima, Carolina Gonçalves Dias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366139/
https://www.ncbi.nlm.nih.gov/pubmed/28340590
http://dx.doi.org/10.1186/s12917-017-0997-4
_version_ 1782517536606126080
author Bonelli, Marília de Albuquerque
da Costa, Ronaldo Casimiro
Martin-Vaquero, Paula
Lima, Carolina Gonçalves Dias
author_facet Bonelli, Marília de Albuquerque
da Costa, Ronaldo Casimiro
Martin-Vaquero, Paula
Lima, Carolina Gonçalves Dias
author_sort Bonelli, Marília de Albuquerque
collection PubMed
description BACKGROUND: Cervical spondylomyelopathy (CSM), also known as wobbler syndrome, affects mainly large and giant-breed dogs, causing compression of the cervical spinal cord and/or nerve roots. Structural and dynamic components seem to play a role in the development of CSM; however, pathogenesis is not yet fully understood. Physiologic and pathologic movements of the cervical spine depend on the morphology and morphometry of articular processes, as well as on intervertebral discs and vertebral column ligaments. Moreover, the characteristics of the articular processes affect motion and stability of the vertebral column. The goal of this study was to investigate the angle, shape, and position of the articular surfaces within the articular processes and compare them between Doberman Pinschers and Great Danes with and without cervical spondylomyelopathy. RESULTS: Magnetic resonance images were obtained for 60 dogs: 15 clinically normal Dobermans (Dob-N), 15 CSM-affected Dobermans (Dob-CSM), 15 clinically normal Great Danes (GD-N), and 15 CSM-affected Great Danes (GD-CSM). Angle, shape, and position (lateral distance) of the articular surfaces from the articular processes were analyzed from C(2–3) to C(7)-T(1). Results indicate that the mean angle was different between Dob-CSM and GD-CSM at C(4–5), C(5–6), and C(6–7), and between GD-N and GD-CSM at C(6–7). There were differences between Dob-N and GD-N, and between Dob-CSM and GD-CSM for the lateral distance at most locations, except C(2–3). Compared with Great Danes, Dobermans generally had a greater proportion of concave caudal surfaces at C(4–5), C(5–6), and C(6–7). Concave articular surfaces have been associated with greater axial rotation. This may explain the high proportion of disc-associated CSM in Dobermans compared to Great Danes. The differences between breeds suggest they may have different motion patterns in the caudal cervical vertebral column. CONCLUSIONS: Considering that no differences in angle, shape, or position of the articular surfaces within the articular processes were found between normal and CSM-affected dogs, their relevance appears to have a secondary role in the pathogenesis of CSM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12917-017-0997-4) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-5366139
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-53661392017-03-28 Comparison of angle, shape, and position of articular processes in Dobermans and Great Danes with and without cervical spondylomyelopathy Bonelli, Marília de Albuquerque da Costa, Ronaldo Casimiro Martin-Vaquero, Paula Lima, Carolina Gonçalves Dias BMC Vet Res Research Article BACKGROUND: Cervical spondylomyelopathy (CSM), also known as wobbler syndrome, affects mainly large and giant-breed dogs, causing compression of the cervical spinal cord and/or nerve roots. Structural and dynamic components seem to play a role in the development of CSM; however, pathogenesis is not yet fully understood. Physiologic and pathologic movements of the cervical spine depend on the morphology and morphometry of articular processes, as well as on intervertebral discs and vertebral column ligaments. Moreover, the characteristics of the articular processes affect motion and stability of the vertebral column. The goal of this study was to investigate the angle, shape, and position of the articular surfaces within the articular processes and compare them between Doberman Pinschers and Great Danes with and without cervical spondylomyelopathy. RESULTS: Magnetic resonance images were obtained for 60 dogs: 15 clinically normal Dobermans (Dob-N), 15 CSM-affected Dobermans (Dob-CSM), 15 clinically normal Great Danes (GD-N), and 15 CSM-affected Great Danes (GD-CSM). Angle, shape, and position (lateral distance) of the articular surfaces from the articular processes were analyzed from C(2–3) to C(7)-T(1). Results indicate that the mean angle was different between Dob-CSM and GD-CSM at C(4–5), C(5–6), and C(6–7), and between GD-N and GD-CSM at C(6–7). There were differences between Dob-N and GD-N, and between Dob-CSM and GD-CSM for the lateral distance at most locations, except C(2–3). Compared with Great Danes, Dobermans generally had a greater proportion of concave caudal surfaces at C(4–5), C(5–6), and C(6–7). Concave articular surfaces have been associated with greater axial rotation. This may explain the high proportion of disc-associated CSM in Dobermans compared to Great Danes. The differences between breeds suggest they may have different motion patterns in the caudal cervical vertebral column. CONCLUSIONS: Considering that no differences in angle, shape, or position of the articular surfaces within the articular processes were found between normal and CSM-affected dogs, their relevance appears to have a secondary role in the pathogenesis of CSM. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12917-017-0997-4) contains supplementary material, which is available to authorized users. BioMed Central 2017-03-24 /pmc/articles/PMC5366139/ /pubmed/28340590 http://dx.doi.org/10.1186/s12917-017-0997-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Bonelli, Marília de Albuquerque
da Costa, Ronaldo Casimiro
Martin-Vaquero, Paula
Lima, Carolina Gonçalves Dias
Comparison of angle, shape, and position of articular processes in Dobermans and Great Danes with and without cervical spondylomyelopathy
title Comparison of angle, shape, and position of articular processes in Dobermans and Great Danes with and without cervical spondylomyelopathy
title_full Comparison of angle, shape, and position of articular processes in Dobermans and Great Danes with and without cervical spondylomyelopathy
title_fullStr Comparison of angle, shape, and position of articular processes in Dobermans and Great Danes with and without cervical spondylomyelopathy
title_full_unstemmed Comparison of angle, shape, and position of articular processes in Dobermans and Great Danes with and without cervical spondylomyelopathy
title_short Comparison of angle, shape, and position of articular processes in Dobermans and Great Danes with and without cervical spondylomyelopathy
title_sort comparison of angle, shape, and position of articular processes in dobermans and great danes with and without cervical spondylomyelopathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366139/
https://www.ncbi.nlm.nih.gov/pubmed/28340590
http://dx.doi.org/10.1186/s12917-017-0997-4
work_keys_str_mv AT bonellimariliadealbuquerque comparisonofangleshapeandpositionofarticularprocessesindobermansandgreatdaneswithandwithoutcervicalspondylomyelopathy
AT dacostaronaldocasimiro comparisonofangleshapeandpositionofarticularprocessesindobermansandgreatdaneswithandwithoutcervicalspondylomyelopathy
AT martinvaqueropaula comparisonofangleshapeandpositionofarticularprocessesindobermansandgreatdaneswithandwithoutcervicalspondylomyelopathy
AT limacarolinagoncalvesdias comparisonofangleshapeandpositionofarticularprocessesindobermansandgreatdaneswithandwithoutcervicalspondylomyelopathy