The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion

DOCK proteins are guanine nucleotide exchange factors for Rac and Cdc42 GTPases. DOCK1 is the founding member of the family and acts downstream of integrins via the canonical Crk-p130Cas complex to activate Rac GTPases in numerous contexts. In contrast, DOCK5, which possesses the greatest similarity...

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Detalles Bibliográficos
Autores principales: Frank, S R, Köllmann, C P, van Lidth de Jeude, J F, Thiagarajah, J R, Engelholm, L H, Frödin, M, Hansen, S H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366285/
https://www.ncbi.nlm.nih.gov/pubmed/27669437
http://dx.doi.org/10.1038/onc.2016.345

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