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Botulism Outbreak in a Family after Ingestion of Locally Produced Cheese

Botulism is one of the most important foodborne diseases and is caused by Clostridium botulinum toxin. The main manifestations are flaccid muscle paralysis and cranial nerve palsies. Botulism is an essential health problem because of its high mortality. The diagnosis of botulism, especially in spora...

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Autores principales: Rafie, Shahram, Salmanzadeh, Shokrollah, Mehramiri, Asieh, Nejati, Adel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Journal of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366369/
https://www.ncbi.nlm.nih.gov/pubmed/28360447
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author Rafie, Shahram
Salmanzadeh, Shokrollah
Mehramiri, Asieh
Nejati, Adel
author_facet Rafie, Shahram
Salmanzadeh, Shokrollah
Mehramiri, Asieh
Nejati, Adel
author_sort Rafie, Shahram
collection PubMed
description Botulism is one of the most important foodborne diseases and is caused by Clostridium botulinum toxin. The main manifestations are flaccid muscle paralysis and cranial nerve palsies. Botulism is an essential health problem because of its high mortality. The diagnosis of botulism, especially in sporadic cases, is a medical challenge and a high clinical suspicion is necessary for early recognition. So, every physician should be familiar with its signs and symptoms for early detection and treatment. We describe a family with dysphasia and acute paralysis after the ingestion of locally made cheese. The clinical presentations of the 1st patient were similar to myasthenic crisis and she, therefore, received plasma exchange. After the appearance of similar symptoms in the other family members, they were treated with polyvalent botulinum antitoxin and diagnosis was confirmed by toxicology and detection of serotype A botulinum toxin in cheese and stool samples. Uncommon clinical presentations and unusual sources of botulinum toxin should be kept in mind because of the importance of early diagnosis and treatment.
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spelling pubmed-53663692017-03-30 Botulism Outbreak in a Family after Ingestion of Locally Produced Cheese Rafie, Shahram Salmanzadeh, Shokrollah Mehramiri, Asieh Nejati, Adel Iran J Med Sci Case Report Botulism is one of the most important foodborne diseases and is caused by Clostridium botulinum toxin. The main manifestations are flaccid muscle paralysis and cranial nerve palsies. Botulism is an essential health problem because of its high mortality. The diagnosis of botulism, especially in sporadic cases, is a medical challenge and a high clinical suspicion is necessary for early recognition. So, every physician should be familiar with its signs and symptoms for early detection and treatment. We describe a family with dysphasia and acute paralysis after the ingestion of locally made cheese. The clinical presentations of the 1st patient were similar to myasthenic crisis and she, therefore, received plasma exchange. After the appearance of similar symptoms in the other family members, they were treated with polyvalent botulinum antitoxin and diagnosis was confirmed by toxicology and detection of serotype A botulinum toxin in cheese and stool samples. Uncommon clinical presentations and unusual sources of botulinum toxin should be kept in mind because of the importance of early diagnosis and treatment. Iranian Journal of Medical Sciences 2017-03 /pmc/articles/PMC5366369/ /pubmed/28360447 Text en Copyright: © Iranian Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Rafie, Shahram
Salmanzadeh, Shokrollah
Mehramiri, Asieh
Nejati, Adel
Botulism Outbreak in a Family after Ingestion of Locally Produced Cheese
title Botulism Outbreak in a Family after Ingestion of Locally Produced Cheese
title_full Botulism Outbreak in a Family after Ingestion of Locally Produced Cheese
title_fullStr Botulism Outbreak in a Family after Ingestion of Locally Produced Cheese
title_full_unstemmed Botulism Outbreak in a Family after Ingestion of Locally Produced Cheese
title_short Botulism Outbreak in a Family after Ingestion of Locally Produced Cheese
title_sort botulism outbreak in a family after ingestion of locally produced cheese
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366369/
https://www.ncbi.nlm.nih.gov/pubmed/28360447
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