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Effectiveness of Biologic Factors in Shoulder Disorders
BACKGROUND: Shoulder pathology can cause significant pain, discomfort, and loss of function that all interfere with activities of daily living and may lead to poor quality of life. Primary osteoarthritis and rotator cuff diseases with its sequalae are the main culprits. Management of shoulder disord...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Open
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366381/ https://www.ncbi.nlm.nih.gov/pubmed/28400884 http://dx.doi.org/10.2174/1874325001711010163 |
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author | Giotis, Dimitrios Aryaei, Ashkan Vasilakakos, Theofanis Paschos, Nikolaos K. |
author_facet | Giotis, Dimitrios Aryaei, Ashkan Vasilakakos, Theofanis Paschos, Nikolaos K. |
author_sort | Giotis, Dimitrios |
collection | PubMed |
description | BACKGROUND: Shoulder pathology can cause significant pain, discomfort, and loss of function that all interfere with activities of daily living and may lead to poor quality of life. Primary osteoarthritis and rotator cuff diseases with its sequalae are the main culprits. Management of shoulder disorders using biological factors gained an increasing interest over the last years. This interest reveals the need of effective treatments for shoulder degenerative disorders, and highlights the importance of a comprehensive and detailed understanding of the rapidly increasing knowledge in the field. METHODS: This study will describe most of the available biology-based strategies that have been recently developed, focusing on their effectiveness in animal and clinical studies. RESULTS: Data from in vitro work will also be briefly presented; in order to further elucidate newly acquired knowledge regarding mechanisms of tissue degeneration and repair that would probably drive translational work in the next decade. The role of platelet rich-plasma, growth factors, stem cells and other alternative treatments will be described in an evidence-based approach, in an attempt to provide guidelines for their clinical application. Finally, certain challenges that biologic treatments face today will be described as an initiative for future strategies. CONCLUSION: The application of different growth factors and mesenchymal stem cells appears as promising approaches for enhancing biologic repair. However, data from clinical studies are still limited, and future studies need to improve understanding of the repair process in cellular and molecular level and evaluate the effectiveness of biologic factors in the management of shoulder disorders. |
format | Online Article Text |
id | pubmed-5366381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-53663812017-04-11 Effectiveness of Biologic Factors in Shoulder Disorders Giotis, Dimitrios Aryaei, Ashkan Vasilakakos, Theofanis Paschos, Nikolaos K. Open Orthop J Article BACKGROUND: Shoulder pathology can cause significant pain, discomfort, and loss of function that all interfere with activities of daily living and may lead to poor quality of life. Primary osteoarthritis and rotator cuff diseases with its sequalae are the main culprits. Management of shoulder disorders using biological factors gained an increasing interest over the last years. This interest reveals the need of effective treatments for shoulder degenerative disorders, and highlights the importance of a comprehensive and detailed understanding of the rapidly increasing knowledge in the field. METHODS: This study will describe most of the available biology-based strategies that have been recently developed, focusing on their effectiveness in animal and clinical studies. RESULTS: Data from in vitro work will also be briefly presented; in order to further elucidate newly acquired knowledge regarding mechanisms of tissue degeneration and repair that would probably drive translational work in the next decade. The role of platelet rich-plasma, growth factors, stem cells and other alternative treatments will be described in an evidence-based approach, in an attempt to provide guidelines for their clinical application. Finally, certain challenges that biologic treatments face today will be described as an initiative for future strategies. CONCLUSION: The application of different growth factors and mesenchymal stem cells appears as promising approaches for enhancing biologic repair. However, data from clinical studies are still limited, and future studies need to improve understanding of the repair process in cellular and molecular level and evaluate the effectiveness of biologic factors in the management of shoulder disorders. Bentham Open 2017-02-28 /pmc/articles/PMC5366381/ /pubmed/28400884 http://dx.doi.org/10.2174/1874325001711010163 Text en © 2017 Giotis et al. https://creativecommons.org/licenses/by/4.0/legalcode This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Article Giotis, Dimitrios Aryaei, Ashkan Vasilakakos, Theofanis Paschos, Nikolaos K. Effectiveness of Biologic Factors in Shoulder Disorders |
title | Effectiveness of Biologic Factors in Shoulder Disorders |
title_full | Effectiveness of Biologic Factors in Shoulder Disorders |
title_fullStr | Effectiveness of Biologic Factors in Shoulder Disorders |
title_full_unstemmed | Effectiveness of Biologic Factors in Shoulder Disorders |
title_short | Effectiveness of Biologic Factors in Shoulder Disorders |
title_sort | effectiveness of biologic factors in shoulder disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366381/ https://www.ncbi.nlm.nih.gov/pubmed/28400884 http://dx.doi.org/10.2174/1874325001711010163 |
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