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Differential roles of caspase-1 and caspase-11 in infection and inflammation
Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis. On activation within an inflammasome complex, caspase-1 induces pyroptosis and converts pro-IL-1β and pro-IL-18 into their...
Autores principales: | Ming Man, Si, Karki, Rajendra, Briard, Benoit, Burton, Amanda, Gingras, Sebastien, Pelletier, Stephane, Kanneganti, Thirumala-Devi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366862/ https://www.ncbi.nlm.nih.gov/pubmed/28345580 http://dx.doi.org/10.1038/srep45126 |
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