HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice

Chronic obstructive pulmonary disease (COPD) constitutes a major health burden. Studying underlying molecular mechanisms could lead to new therapeutic targets. Macrophages are orchestrators of COPD, by releasing pro-inflammatory cytokines. This process relies on transcription factors such as NF-κB,...

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Detalles Bibliográficos
Autores principales: Leus, Niek G. J., van den Bosch, Thea, van der Wouden, Petra E., Krist, Kim, Ourailidou, Maria E., Eleftheriadis, Nikolaos, Kistemaker, Loes E. M., Bos, Sophie, Gjaltema, Rutger A. F., Mekonnen, Solomon A., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366870/
https://www.ncbi.nlm.nih.gov/pubmed/28344354
http://dx.doi.org/10.1038/srep45047

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